Ethyl 3-((tert-butoxycarbonylamino)methyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate

Base Information

Chemical Name:Ethyl 3-((tert-butoxycarbonylamino)methyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate
CAS No.:915297-00-6
Molecular Formula:C₂₃H₂₅Cl₂N₃O₅
Molecular Weight:494.375
Hs Code.:

Synonyms:Ethyl 3-((tert-butoxycarbonylamino)methyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate

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Chemical Property of Ethyl 3-((tert-butoxycarbonylamino)methyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate

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Technology Process of Ethyl 3-((tert-butoxycarbonylamino)methyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate

There total 11 articles about Ethyl 3-((tert-butoxycarbonylamino)methyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 915296-99-0
C₂₀H₂₁Cl₂N₃O₃

: 541-41-3
chloroformic acid ethyl ester

: 915297-00-6
Ethyl 3-((tert-butoxycarbonylamino)methyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: C₁₅H₁₀Cl₂N₂O₃

: 915297-00-6
Ethyl 3-((tert-butoxycarbonylamino)methyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / tetrahydrofuran / Inert atmosphere

2: sodium tetrahydroborate / water; tetrahydrofuran / Inert atmosphere

3: triethylamine; methanesulfonyl chloride / dichloromethane / Inert atmosphere

4: ammonia / methanol / 100 °C / Microwave irradiation; Inert atmosphere

5: ammonia / tetrahydrofuran / 20 °C / Inert atmosphere

6: dmap; triethylamine / dichloromethane / 20 °C / Inert atmosphere

With dmap; sodium tetrahydroborate; ammonia; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm4008906

Reference yield:

: C₁₈H₁₄Cl₂N₂O₅

: 915297-00-6
Ethyl 3-((tert-butoxycarbonylamino)methyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tetrahydroborate / water; tetrahydrofuran / Inert atmosphere

2: triethylamine; methanesulfonyl chloride / dichloromethane / Inert atmosphere

3: ammonia / methanol / 100 °C / Microwave irradiation; Inert atmosphere

4: ammonia / tetrahydrofuran / 20 °C / Inert atmosphere

5: dmap; triethylamine / dichloromethane / 20 °C / Inert atmosphere

With dmap; sodium tetrahydroborate; ammonia; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm4008906