7-(4-aminophenyl)-2-(4-chlorophenyl)-2,5-dihydro-6-methylpyrazolo[4,3-c]pyridin-3-one

Base Information

• Chemical Name: 7-(4-aminophenyl)-2-(4-chlorophenyl)-2,5-dihydro-6-methylpyrazolo[4,3-c]pyridin-3-one
• CAS No.: 244637-51-2
• Molecular Formula: C₁₉H₁₅ClN₄O
• Molecular Weight: 350.807

Synonyms:7-(4-aminophenyl)-2-(4-chlorophenyl)-2,5-dihydro-6-methylpyrazolo[4,3-c]pyridin-3-one

Chemical Property of 7-(4-aminophenyl)-2-(4-chlorophenyl)-2,5-dihydro-6-methylpyrazolo[4,3-c]pyridin-3-one

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 7-(4-aminophenyl)-2-(4-chlorophenyl)-2,5-dihydro-6-methylpyrazolo[4,3-c]pyridin-3-one

There total 5 articles about 7-(4-aminophenyl)-2-(4-chlorophenyl)-2,5-dihydro-6-methylpyrazolo[4,3-c]pyridin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-Chlorophenyl)-2,5-dihydro-6-methyl-7-(4-nitrophenyl]pyrazolo[4,3-c]pyridin-3-one (244638-72-0) → 7-(4-aminophenyl)-2-(4-chlorophenyl)-2,5-dihydro-6-methylpyrazolo[4,3-c]pyridin-3-one (244637-51-2)

Guidance literature:

With copper acetylacetonate; sodium tetrahydroborate; In ethanol;

DOI:10.1016/j.bmcl.2005.08.006

Reference yield:

Ethyl 4-chloro-2-methyl-3-(4-nitrophenyl)-5-pyridinecarboxylate (244638-71-9) → 7-(4-aminophenyl)-2-(4-chlorophenyl)-2,5-dihydro-6-methylpyrazolo[4,3-c]pyridin-3-one (244637-51-2)

Guidance literature:

Multi-step reaction with 2 steps

1: butan-1-ol / Heating

2: Cu(acac)2; NaBH₄ / ethanol

With copper acetylacetonate; sodium tetrahydroborate; In ethanol; butan-1-ol;

DOI:10.1016/j.bmcl.2005.08.006

Reference yield:

Ethyl 1,4-dihydro-2-methyl-3-(4-nitrophenyl)-4-oxo-5-pyridinecarboxylate (244638-70-8) → 7-(4-aminophenyl)-2-(4-chlorophenyl)-2,5-dihydro-6-methylpyrazolo[4,3-c]pyridin-3-one (244637-51-2)

Guidance literature:

Multi-step reaction with 3 steps

1: phosphorus oxychloride / Heating

2: butan-1-ol / Heating

3: Cu(acac)2; NaBH₄ / ethanol

With copper acetylacetonate; sodium tetrahydroborate; trichlorophosphate; In ethanol; butan-1-ol;

DOI:10.1016/j.bmcl.2005.08.006

upstream raw materials:

2-(4-Chlorophenyl)-2,5-dihydro-6-methyl-7-(4-nitrophenyl]pyrazolo[4,3-c]pyridin-3-one

Ethyl 4-chloro-2-methyl-3-(4-nitrophenyl)-5-pyridinecarboxylate

Ethyl 1,4-dihydro-2-methyl-3-(4-nitrophenyl)-4-oxo-5-pyridinecarboxylate

2-{[(Z)-1-Methyl-2-(4-nitro-phenyl)-vinylamino]-methylene}-malonic acid diethyl ester

Downstream raw materials:

methanesulfonic acid 3-{4-[2-(4-chloro-phenyl)-6-methyl-3-oxo-3,5-dihydro-2H-pyrazolo[4,3-c]pyridin-7-yl]-phenyl}-prop-2-ynyl ester

7-[4-(3-azido-prop-1-ynyl)-phenyl]-2-(4-chloro-phenyl)-6-methyl-2,5-dihydro-pyrazolo[4,3-c]pyridin-3-one

2-(4-chlorophenyl)-2,5-dihydro-7-[4-(3-hydroxyprop-1-yn-1-yl)phenyl]-6-methylpyrazolo[4,3-c]pyridin-3-one

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