244638-71-9

Upstream product

• 244638-70-8 Ethyl 1,4-dihydro-2-methyl-3-(4-nitrophenyl)-4-oxo-5-pyridinecarboxylate 
• 6296-99-7 diethyl aminomethylenemalonate 
• 5332-96-7 1-(4-nitrophenyl)propan-2-one 
• 868363-14-8 2-{[(Z)-1-Methyl-2-(4-nitro-phenyl)-vinylamino]-methylene}-malonic acid diethyl ester 

Downstream Products

• 868363-26-2 methanesulfonic acid 3-{4-[2-(4-chloro-phenyl)-6-methyl-3-oxo-3,5-dihydro-2H-pyrazolo[4,3-c]pyridin-7-yl]-phenyl}-prop-2-ynyl ester 
• 868363-27-3 7-[4-(3-azido-prop-1-ynyl)-phenyl]-2-(4-chloro-phenyl)-6-methyl-2,5-dihydro-pyrazolo[4,3-c]pyridin-3-one 
• 244637-81-8 2-(4-chlorophenyl)-2,5-dihydro-7-[4-(3-hydroxyprop-1-yn-1-yl)phenyl]-6-methylpyrazolo[4,3-c]pyridin-3-one 
• 244637-74-9 2-(4-chlorophenyl)-2,5-dihydro-7-(4-iodophenyl)-6-methylpyrazolo[4,3-c]pyridin-3-one 
• 244637-51-2 7-(4-aminophenyl)-2-(4-chlorophenyl)-2,5-dihydro-6-methylpyrazolo[4,3-c]pyridin-3-one 
• 244638-72-0 2-(4-Chlorophenyl)-2,5-dihydro-6-methyl-7-(4-nitrophenyl]pyrazolo[4,3-c]pyridin-3-one 

Relevant academic research and scientific papers

Pyrazolopyridinones as functionally selective GABAA ligands

2,5-Dihydro-3H-pyrazolo[4,3-c]pyridin-3-ones are GABAA receptor benzodiazepine binding site ligands, which can exhibit functional selectivity for the α3 subtype over the α1 subtype. SAR studies to optimize this functional

Pyrazolo-pyridine derivatives as ligands for GABA receptors

Pyrazolo[4,3-c]pyridin-3-one derivatives substituted at the 2-position by an optionally substituted aryl or heteroaryl moiety, and having pendant substituents at the 7-position and optionally also at the 6-position, are selective ligands for GABAAreceptors, particularly having high affinity for the α2 and/or α3 subunit, and are useful in the treatment and/or prevention of disorders of the central nervous system, including anxiety and convulsions.