4'-(2,4-Difluorophenoxy)acetophenone

Base Information

• Chemical Name: 4'-(2,4-Difluorophenoxy)acetophenone
• CAS No.: 845823-27-0
• Molecular Formula: C₁₄H₁₀F₂O₂
• Molecular Weight: 248.229
• DSSTox Substance ID: DTXSID20374275
• Wikidata: Q82162805
• Mol file: 845823-27-0.mol

Synonyms:4'-(2,4-Difluorophenoxy)acetophenone;845823-27-0;1-[4-(2,4-difluorophenoxy)phenyl]ethanone;SCHEMBL11548018;DTXSID20374275;AKOS000219762

Chemical Property of 4'-(2,4-Difluorophenoxy)acetophenone

Chemical Property:

• Melting Point: 58-62°C
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 248.06488588
• Heavy Atom Count: 18
• Complexity: 288

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(=O)C1=CC=C(C=C1)OC2=C(C=C(C=C2)F)F

Technology Process of 4'-(2,4-Difluorophenoxy)acetophenone

There total 1 articles about 4'-(2,4-Difluorophenoxy)acetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-difluorophenol (367-27-1) + 1-(4-fluorophenyl)ethanone (403-42-9) → p-2,4-difluorophenoxyacetophenone (845823-27-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl acetamide; at 150 ℃; for 16h;

DOI:10.1021/jm030498q

Reference yield: 94.5%

carbonic acid dimethyl ester (616-38-6) + p-2,4-difluorophenoxyacetophenone (845823-27-0) → methyl 3-(4-(2,4-difluorophenoxy)phenyl)-3-oxopropanoate

Guidance literature:

p-2,4-difluorophenoxyacetophenone; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h;

carbonic acid dimethyl ester; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 2h;

DOI:10.1016/j.ejmech.2021.113724

Reference yield:

(2-(benzyloxy)ethyl)magnesium bromide + 1-benzyloxy-3-p-(2,4-difluorophenoxy)phenylbutan-3-ol + p-2,4-difluorophenoxyacetophenone (845823-27-0) → 3-p-(2,4-difluorophenoxy)-phenylbutane-1,3-diol (62575-22-8)

Guidance literature:

Pd-C; In methanol;

upstream raw materials:

2,4-difluorophenol

1-(4-fluorophenyl)ethanone

Downstream raw materials:

3-[4-(2,4-difluoro-phenoxy)-phenyl]-1H-pyrazole

3-p-(2,4-difluorophenoxy)-phenylbutane-1,3-diol

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