5-{(S)-4-{[(Benzhydryl-carbamoyl)-methoxycarbonylmethyl]-carbamoyl}-4-[(S)-2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-butylcarbamoyl}-pentanoic acid benzyl ester

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Chemical Name:5-{(S)-4-{[(Benzhydryl-carbamoyl)-methoxycarbonylmethyl]-carbamoyl}-4-[(S)-2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-butylcarbamoyl}-pentanoic acid benzyl ester
CAS No.:209270-25-7
Molecular Formula:C₄₉H₅₉N₅O₁₁
Molecular Weight:894.034
Hs Code.:

5-{(S)-4-{[(Benzhydryl-carbamoyl)-methoxycarbonylmethyl]-carbamoyl}-4-[(S)-2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-butylcarbamoyl}-pentanoic acid benzyl ester

Synonyms:5-{(S)-4-{[(Benzhydryl-carbamoyl)-methoxycarbonylmethyl]-carbamoyl}-4-[(S)-2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-butylcarbamoyl}-pentanoic acid benzyl ester

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Chemical Property of 5-{(S)-4-{[(Benzhydryl-carbamoyl)-methoxycarbonylmethyl]-carbamoyl}-4-[(S)-2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-butylcarbamoyl}-pentanoic acid benzyl ester

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Technology Process of 5-{(S)-4-{[(Benzhydryl-carbamoyl)-methoxycarbonylmethyl]-carbamoyl}-4-[(S)-2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-butylcarbamoyl}-pentanoic acid benzyl ester

There total 5 articles about 5-{(S)-4-{[(Benzhydryl-carbamoyl)-methoxycarbonylmethyl]-carbamoyl}-4-[(S)-2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-butylcarbamoyl}-pentanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 40542-90-3
adipic acid monobenzyl ester

: 1053419-40-1
{(S)-5-Amino-2-[(S)-2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-pentanoylamino}-acetic acid (benzhydryl-carbamoyl)-methyl ester

: 209270-25-7
5-{(S)-4-{[(Benzhydryl-carbamoyl)-methoxycarbonylmethyl]-carbamoyl}-4-[(S)-2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-butylcarbamoyl}-pentanoic acid benzyl ester

Guidance literature:: With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1016/S0223-5234(98)80006-8

Reference yield:

: 2480-93-5
Boc-Orn(Z)-OH

: 209270-25-7
5-{(S)-4-{[(Benzhydryl-carbamoyl)-methoxycarbonylmethyl]-carbamoyl}-4-[(S)-2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-butylcarbamoyl}-pentanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1) N-methylmorpholine, iBuOCOCl, 2) TFA, N-methylmorpholine / 1) DMF, -20 deg C, 5 min, 2) DMF, r.t., 1 h

2: 1) TFA, 2) DIEA / 2) DMF, r.t., 1 h

3: H₂, conc. HCl / 10percent Pd/C / ethanol / Ambient temperature

4: 75 percent / (benzotriazol-1-yloxy)-tris(dimethylamino)phosphonium hexafluorophosphate, N-methylmorpholine / dimethylformamide / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; isobutyl chloroformate; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0223-5234(98)80006-8

Reference yield:

: H-Gly-OBg

: 209270-25-7
5-{(S)-4-{[(Benzhydryl-carbamoyl)-methoxycarbonylmethyl]-carbamoyl}-4-[(S)-2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-butylcarbamoyl}-pentanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1) N-methylmorpholine, iBuOCOCl, 2) TFA, N-methylmorpholine / 1) DMF, -20 deg C, 5 min, 2) DMF, r.t., 1 h

2: 1) TFA, 2) DIEA / 2) DMF, r.t., 1 h

3: H₂, conc. HCl / 10percent Pd/C / ethanol / Ambient temperature

4: 75 percent / (benzotriazol-1-yloxy)-tris(dimethylamino)phosphonium hexafluorophosphate, N-methylmorpholine / dimethylformamide / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; isobutyl chloroformate; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0223-5234(98)80006-8