[2-phenyl-5-(2-phenyl-1H-indole-6-carbonyl)thiophene-3-yl]acetic acid methyl ester

Base Information

Chemical Name:[2-phenyl-5-(2-phenyl-1H-indole-6-carbonyl)thiophene-3-yl]acetic acid methyl ester
CAS No.:875271-85-5
Molecular Formula:C₂₈H₂₁NO₃S
Molecular Weight:451.546
Hs Code.:

Synonyms:[2-phenyl-5-(2-phenyl-1H-indole-6-carbonyl)thiophene-3-yl]acetic acid methyl ester

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Chemical Property of [2-phenyl-5-(2-phenyl-1H-indole-6-carbonyl)thiophene-3-yl]acetic acid methyl ester

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Technology Process of [2-phenyl-5-(2-phenyl-1H-indole-6-carbonyl)thiophene-3-yl]acetic acid methyl ester

There total 15 articles about [2-phenyl-5-(2-phenyl-1H-indole-6-carbonyl)thiophene-3-yl]acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1304126-87-1
methyl (2-phenyl-5-(2-phenyl-1-[2-(trimethylsilyl)-ethoxymethyl]-indole-6-carbonyl)thiophen-3-yl)acetate

: 875271-85-5
[2-phenyl-5-(2-phenyl-1H-indole-6-carbonyl)thiophene-3-yl]acetic acid methyl ester

Guidance literature:: With tetrabutyl ammonium fluoride; ethylenediamine; In N,N-dimethyl-formamide; at 80 ℃; for 3h; Microwave irradiation;
DOI:10.1039/c1cc10755k

Reference yield: 61.0%

: 875271-88-8
{5-[3-amino-4-(phenylethynyl)benzoyl]-2-phenylthiophene-3-yl}acetic acid methyl ester

: 875271-85-5
[2-phenyl-5-(2-phenyl-1H-indole-6-carbonyl)thiophene-3-yl]acetic acid methyl ester

Guidance literature:: bis(benzonitrile)palladium(II) dichloride; In N,N-dimethyl-formamide; at 80 ℃; for 0.5h;
DOI:10.1016/j.bmc.2005.08.018

Reference yield:

: 875271-79-7
(2-phenylthiophen-3-yl)acetic acid methyl ester

: 875271-85-5
[2-phenyl-5-(2-phenyl-1H-indole-6-carbonyl)thiophene-3-yl]acetic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 74 percent / AlCl₃ / CH₂Cl₂ / 20 °C

2: 96 percent / stannous chloride dihydrate / ethyl acetate / 0.5 h / Heating

3: 98 percent / Et₂NH; CuI / Pd(PPh₃)4 / 4 h / 20 °C

4: 61 percent / PdCl₂(PhCN)2 / dimethylformamide / 0.5 h / 80 °C

With copper(l) iodide; aluminium trichloride; diethylamine; tin(ll) chloride; bis(benzonitrile)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 1: Friedel-Crafts reaction;
DOI:10.1016/j.bmc.2005.08.018