methyl (2-phenyl-5-(2-phenyl-1-[2-(trimethylsilyl)-ethoxymethyl]-indole-6-carbonyl)thiophen-3-yl)acetate

Base Information

Chemical Name:methyl (2-phenyl-5-(2-phenyl-1-[2-(trimethylsilyl)-ethoxymethyl]-indole-6-carbonyl)thiophen-3-yl)acetate
CAS No.:1304126-87-1
Molecular Formula:C₃₄H₃₅NO₄SSi
Molecular Weight:581.808
Hs Code.:

Synonyms:methyl (2-phenyl-5-(2-phenyl-1-[2-(trimethylsilyl)-ethoxymethyl]-indole-6-carbonyl)thiophen-3-yl)acetate

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Chemical Property of methyl (2-phenyl-5-(2-phenyl-1-[2-(trimethylsilyl)-ethoxymethyl]-indole-6-carbonyl)thiophen-3-yl)acetate

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Technology Process of methyl (2-phenyl-5-(2-phenyl-1-[2-(trimethylsilyl)-ethoxymethyl]-indole-6-carbonyl)thiophen-3-yl)acetate

There total 7 articles about methyl (2-phenyl-5-(2-phenyl-1-[2-(trimethylsilyl)-ethoxymethyl]-indole-6-carbonyl)thiophen-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 591-50-4
iodobenzene

: 1304126-86-0
methyl 5-(2-phenyl-1-[2-(trimethylsilyl)-ethoxymethyl]-indole-6-carbonyl)thiophen-3-ylacetate

: 1304126-87-1
methyl (2-phenyl-5-(2-phenyl-1-[2-(trimethylsilyl)-ethoxymethyl]-indole-6-carbonyl)thiophen-3-yl)acetate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; potassium fluoride; silver nitrate; In dimethyl sulfoxide; at 120 ℃; for 3h; Microwave irradiation;
DOI:10.1039/c1cc10755k

Reference yield:

: 1304126-85-9
2-phenyl-1-[2-(trimethylsilyl)-ethoxymethyl]-indole-6-carboxylic acid

: 1304126-87-1
methyl (2-phenyl-5-(2-phenyl-1-[2-(trimethylsilyl)-ethoxymethyl]-indole-6-carbonyl)thiophen-3-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride / dichloromethane / 2 h / 20 °C

2: n-butyllithium / tetrahydrofuran / 2.25 h / -78 °C

3: bis-triphenylphosphine-palladium(II) chloride; potassium fluoride; silver nitrate / dimethyl sulfoxide / 3 h / 120 °C / Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; potassium fluoride; n-butyllithium; oxalyl dichloride; silver nitrate; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; 2: Friedel Crafts acylation;
DOI:10.1039/c1cc10755k

Reference yield:

: 1247072-06-5
methyl 2-phenyl-1-[2-(trimethylsilyl)ethoxymethyl]-indole-6-carboxylate

: 1304126-87-1
methyl (2-phenyl-5-(2-phenyl-1-[2-(trimethylsilyl)-ethoxymethyl]-indole-6-carbonyl)thiophen-3-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: water; sodium hydroxide / dimethyl sulfoxide / 2 h / 20 °C

2: oxalyl dichloride / dichloromethane / 2 h / 20 °C

3: n-butyllithium / tetrahydrofuran / 2.25 h / -78 °C

4: bis-triphenylphosphine-palladium(II) chloride; potassium fluoride; silver nitrate / dimethyl sulfoxide / 3 h / 120 °C / Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; potassium fluoride; n-butyllithium; oxalyl dichloride; water; silver nitrate; sodium hydroxide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; 3: Friedel Crafts acylation;
DOI:10.1039/c1cc10755k