1-[4-(6-bromo-8-methyloxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]-cyclobutanamine

Base Information

Chemical Name:1-[4-(6-bromo-8-methyloxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]-cyclobutanamine
CAS No.:1402608-04-1
Molecular Formula:C₂₃H₂₁BrN₄O
Molecular Weight:449.35
Hs Code.:

Synonyms:1-[4-(6-bromo-8-methyloxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]-cyclobutanamine

Suppliers and Price of 1-[4-(6-bromo-8-methyloxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]-cyclobutanamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-[4-(6-bromo-8-methyloxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]-cyclobutanamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-[4-(6-bromo-8-methyloxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]-cyclobutanamine

There total 3 articles about 1-[4-(6-bromo-8-methyloxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]-cyclobutanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 1402608-89-2
tert-butyl (1-{4-[3-phenyl-6-bromo-8-methoxyimidazo[1,2-b]pyridazin-2-yl]-phenyl}cyclobutyl)carbamate

: 1402608-04-1
1-[4-(6-bromo-8-methyloxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]-cyclobutanamine

Guidance literature:: tert-butyl (1-{4-[3-phenyl-6-bromo-8-methoxyimidazo[1,2-b]pyridazin-2-yl]-phenyl}cyclobutyl)carbamate; With trifluorormethanesulfonic acid; In 1,4-dioxane; at 20 ℃; for 12h;

With sodium hydroxide; In 1,4-dioxane; water; pH=> 7; Cooling with ice;

Reference yield:

: 1402608-82-5
tert-butyl (1-{4-[3-phenyl-6,8-dibromoimidazo[1,2-b]pyridazin-2-yl]-phenyl}cyclobutyl)carbamate

: 1402608-04-1
1-[4-(6-bromo-8-methyloxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]-cyclobutanamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol / 4 h / 20 °C / Cooling with ice

2.1: trifluorormethanesulfonic acid / 1,4-dioxane / 12 h / 20 °C

2.2: pH > 7 / Cooling with ice

With trifluorormethanesulfonic acid; In 1,4-dioxane; methanol;

Reference yield:

: 1355999-71-1
tert-butyl 1-(4-(2-bromo-2-phenylacetyl)phenyl)cyclobutylcarbamate

: 1402608-04-1
1-[4-(6-bromo-8-methyloxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]-cyclobutanamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 8 h / Reflux

2.1: methanol / 4 h / 20 °C / Cooling with ice

3.1: trifluorormethanesulfonic acid / 1,4-dioxane / 12 h / 20 °C

3.2: pH > 7 / Cooling with ice

With trifluorormethanesulfonic acid; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; isopropyl alcohol;