[(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxy]-2-(4-hydroxy-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid benzhydryl ester

Base Information

Chemical Name:[(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxy]-2-(4-hydroxy-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid benzhydryl ester
CAS No.:185141-93-9
Molecular Formula:C₅₄H₅₉N₄O₁₀P
Molecular Weight:955.057
Hs Code.:

[(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxy]-2-(4-hydroxy-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid benzhydryl ester

Synonyms:[(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxy]-2-(4-hydroxy-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid benzhydryl ester

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Chemical Property of [(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxy]-2-(4-hydroxy-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid benzhydryl ester

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Technology Process of [(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxy]-2-(4-hydroxy-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid benzhydryl ester

There total 14 articles about [(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxy]-2-(4-hydroxy-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 102691-36-1
N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

: 185141-90-6
[(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-2-(4-hydroxy-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid benzhydryl ester

: 185141-93-9
[(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxy]-2-(4-hydroxy-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid benzhydryl ester

Guidance literature:: With N,N-diisopropylamine tetrazolide; In dichloromethane; for 16h;
DOI:10.1021/jo9614607

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 185141-93-9
[(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxy]-2-(4-hydroxy-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / pyridine / CH₂Cl₂ / 1 h

2: 94 percent / diisopropylammonium tetrazolide / CH₂Cl₂ / 16 h

With pyridine; N,N-diisopropylamine tetrazolide; In dichloromethane;
DOI:10.1021/jo9614607

Reference yield:

: 1-((2R,3R,3aS,9aR)-3-Allyl-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-4-hydroxy-1H-pyrimidin-2-one

: 185141-93-9
[(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxy]-2-(4-hydroxy-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 99.6 percent / N-methylmorpholine N-oxide, OsO₄ / acetone; H₂O / 1.5 h

2: NaIO₄ / dioxane; H₂O / 0.17 h

3: 94 percent / 2-methyl-2-butene, NaClo₂, KH₂PO₄ / 2-methyl-propan-2-ol; H₂O / 1 h

4: 75 percent / acetone / 4 h

5: 87 percent / Et₃N*HF / tetrahydrofuran

6: 86 percent / pyridine / CH₂Cl₂ / 1 h

7: 94 percent / diisopropylammonium tetrazolide / CH₂Cl₂ / 16 h

With pyridine; sodium chlorite; sodium periodate; potassium dihydrogenphosphate; osmium(VIII) oxide; 2-methyl-but-2-ene; N,N-diisopropylamine tetrazolide; 4-methylmorpholine N-oxide; triethylamine hydrofluoride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetone; tert-butyl alcohol;
DOI:10.1021/jo9614607