(E)-1-(2-hydroxyphenyl)-4-methyl-6-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1,3,5-hexatriene

Base Information

Chemical Name:(E)-1-(2-hydroxyphenyl)-4-methyl-6-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1,3,5-hexatriene
CAS No.:77837-59-3
Molecular Formula:C₂₂H₂₈O
Molecular Weight:308.464
Hs Code.:

Synonyms:(E)-1-(2-hydroxyphenyl)-4-methyl-6-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1,3,5-hexatriene

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Chemical Property of (E)-1-(2-hydroxyphenyl)-4-methyl-6-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1,3,5-hexatriene

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Technology Process of (E)-1-(2-hydroxyphenyl)-4-methyl-6-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1,3,5-hexatriene

There total 8 articles about (E)-1-(2-hydroxyphenyl)-4-methyl-6-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1,3,5-hexatriene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 77837-72-0
(E)-1-<2-(tetrahydropyranyloxy)phenyl>-4-methyl-6-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1,3,5-hexatriene

: 77837-59-3
(E)-1-(2-hydroxyphenyl)-4-methyl-6-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1,3,5-hexatriene

Guidance literature:: With toluene-4-sulfonic acid; In methanol; ethyl acetate; for 1h;
DOI:10.1021/jm00137a019

Reference yield: 94.0%

: 77837-72-0,77837-73-1
2-{2-[(1Z,3E,5E)-4-Methyl-6-(2,6,6-trimethyl-cyclohex-1-enyl)-hexa-1,3,5-trienyl]-phenoxy}-tetrahydro-pyran

: 77837-59-3,77837-74-2
(1E,3Z,5E)-1-(2-hydroxyphenyl)-4-methyl-6-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1,3,5-hexatriene

Guidance literature:: With toluene-4-sulfonic acid; In methanol; ethyl acetate; for 1h;
DOI:10.1021/jm00137a019

Reference yield:

: 614-60-8
o-Coumaric acid

: 77837-59-3,77837-74-2
(1E,3Z,5E)-1-(2-hydroxyphenyl)-4-methyl-6-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1,3,5-hexatriene

Guidance literature:: Multi-step reaction with 6 steps

1: 6.5 g / p-TsOH*H₂O / toluene / 5 h / Heating

2: p-TsOH*H₂O / 0.25 h / 0 °C

3: DIBAL / diethyl ether; hexane / 0.5 h / 0 °C

4: MnO₂ / diethyl ether

5: NaH, Me₂SO / pentane / 1.) RT, 16 h, 2.) 60 deg C, 1 h

6: 94 percent / p-TsOH*H₂O / methanol; ethyl acetate / 1 h

With manganese(IV) oxide; sodium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; In methanol; diethyl ether; hexane; ethyl acetate; toluene; pentane;
DOI:10.1021/jm00137a019