diethyl 2-(1-(2-chlorophenyl)-3-oxo-3-phenylpropyl)malonate

Base Information

• Chemical Name: diethyl 2-(1-(2-chlorophenyl)-3-oxo-3-phenylpropyl)malonate
• CAS No.: 1172113-17-5
• Molecular Formula: C₂₂H₂₃ClO₅
• Molecular Weight: 402.875
• Mol file: 1172113-17-5.mol

Synonyms:diethyl 2-(1-(2-chlorophenyl)-3-oxo-3-phenylpropyl)malonate

Chemical Property of diethyl 2-(1-(2-chlorophenyl)-3-oxo-3-phenylpropyl)malonate

Chemical Property:

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Technology Process of diethyl 2-(1-(2-chlorophenyl)-3-oxo-3-phenylpropyl)malonate

There total 1 articles about diethyl 2-(1-(2-chlorophenyl)-3-oxo-3-phenylpropyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-(2-chlorophenyl)-1-phenylpropenone (3300-67-2) + diethyl malonate (105-53-3) → diethyl 2-(1-(2-chlorophenyl)-3-oxo-3-phenylpropyl)malonate (1172113-17-5)

Guidance literature:

With bis(diisopropylamino)cyclopropenium tetraphenylborate; caesium carbonate; In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1039/c7ob02882b

Reference yield: 92.0%

diethyl 2-(1-(2-chlorophenyl)-3-oxo-3-phenylpropyl)malonate (1172113-17-5) → diethyl 2-benzoyl-3-(2-chlorophenyl)cyclopropane-1,1-dicarboxylate

Guidance literature:

With iodosylbenzene; tetra-(n-butyl)ammonium iodide; In methanol; at 30 ℃; for 3h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;

DOI:10.1021/ol9012102

Reference yield: 61.0%

diethyl 2-(1-(2-chlorophenyl)-3-oxo-3-phenylpropyl)malonate (1172113-17-5) → diethyl 4-benzoyl-3-(2-chlorophenyl)oxetane-2,2-dicarboxylate + diethyl 2-benzoyl-3-(2-chlorophenyl)cyclopropane-1,1-dicarboxylate

Guidance literature:

With iodosylbenzene; silica gel; tetra-(n-butyl)ammonium iodide; sodium carbonate; In water; at 30 ℃; for 96h; optical yield given as %ee; diastereoselective reaction; Inert atmosphere;

DOI:10.1021/ol9012102

upstream raw materials:

3-(2-chlorophenyl)-1-phenylpropenone

diethyl malonate