N²,N⁴-bis(4-bromophenyl)-6-(piperazin-1-yl)-1,3,5-triazine-2,4-diamine

Base Information

• Chemical Name: N²,N⁴-bis(4-bromophenyl)-6-(piperazin-1-yl)-1,3,5-triazine-2,4-diamine
• CAS No.: 1453805-39-4
• Molecular Formula: C₁₉H₁₉Br₂N₇
• Molecular Weight: 505.215

Synonyms:N²,N⁴-bis(4-bromophenyl)-6-(piperazin-1-yl)-1,3,5-triazine-2,4-diamine

Chemical Property of N²,N⁴-bis(4-bromophenyl)-6-(piperazin-1-yl)-1,3,5-triazine-2,4-diamine

Chemical Property:

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Technology Process of N²,N⁴-bis(4-bromophenyl)-6-(piperazin-1-yl)-1,3,5-triazine-2,4-diamine

There total 2 articles about N²,N⁴-bis(4-bromophenyl)-6-(piperazin-1-yl)-1,3,5-triazine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

piperazine (110-85-0) + N2,N4-bis(4-bromophenyl)-6-chloro-1,3,5-triazine-2,4-diamine (62785-05-1) → N2,N4-bis(4-bromophenyl)-6-(piperazin-1-yl)-1,3,5-triazine-2,4-diamine (1453805-39-4)

Guidance literature:

With potassium carbonate; In 1,4-dioxane; at 120 - 130 ℃;

DOI:10.1039/c2ra21915h

Reference yield:

4-bromo-aniline (106-40-1) → N2,N4-bis(4-bromophenyl)-6-(piperazin-1-yl)-1,3,5-triazine-2,4-diamine (1453805-39-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / acetone / 4 h / 0 - 45 °C

2: potassium carbonate / 1,4-dioxane / 120 - 130 °C

With sodium hydrogencarbonate; potassium carbonate; In 1,4-dioxane; acetone;

DOI:10.1039/c2ra21915h

Reference yield: 71.0%

7-chloro-4-isothiocyanatoquinoline (884647-32-9) + N2,N4-bis(4-bromophenyl)-6-(piperazin-1-yl)-1,3,5-triazine-2,4-diamine (1453805-39-4) → 4-(4,6-bis(4-bromophenylamino)-1,3,5-triazin-2-yl)-N-(7-chloroquinolin-4-yl)piperazine-1-carbothioamide (1453805-40-7)

Guidance literature:

In acetone; at 40 - 45 ℃; for 18h;

DOI:10.1039/c2ra21915h

upstream raw materials:

piperazine

N²,N⁴-bis(4-bromophenyl)-6-chloro-1,3,5-triazine-2,4-diamine

4-bromo-aniline

Downstream raw materials:

4-(4,6-bis(4-bromophenylamino)-1,3,5-triazin-2-yl)-N-(7-chloroquinolin-4-yl)piperazine-1-carbothioamide

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