N-(2-(((2-((2-methoxy-4-morpholinophenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide

Base Information

• Chemical Name: N-(2-(((2-((2-methoxy-4-morpholinophenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide
• CAS No.: 1372262-62-8
• Molecular Formula: C₂₆H₃₁N₇O₄S
• Molecular Weight: 537.643
• Mol file: 1372262-62-8.mol

Synonyms:N-(2-(((2-((2-methoxy-4-morpholinophenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide

Chemical Property of N-(2-(((2-((2-methoxy-4-morpholinophenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-(((2-((2-methoxy-4-morpholinophenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide

There total 7 articles about N-(2-(((2-((2-methoxy-4-morpholinophenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

C33H37N7O6S2 → N-(2-(((2-((2-methoxy-4-morpholinophenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide (1372262-62-8)

Guidance literature:

With sodium hydroxide; In methanol; at 40 ℃; for 10h;

DOI:10.1016/j.ejmech.2019.111716

Reference yield:

2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine (90213-66-4) → N-(2-(((2-((2-methoxy-4-morpholinophenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide (1372262-62-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

1.2: 4 h / 0 °C

2.1: N-ethyl-N,N-diisopropylamine / 5 h / 100 °C

3.1: XPhos; caesium carbonate; palladium diacetate / 1,4-dioxane / 90 °C / Inert atmosphere

4.1: sodium hydroxide / methanol / 10 h / 40 °C

With palladium diacetate; sodium hydride; caesium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; XPhos; In tetrahydrofuran; 1,4-dioxane; methanol;

DOI:10.1016/j.ejmech.2019.111716

Reference yield:

N-(2-cyanophenyl)-N-methylmethanesulfonamide (1073159-70-2) → N-(2-(((2-((2-methoxy-4-morpholinophenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide (1372262-62-8)

Guidance literature:

Multi-step reaction with 4 steps

1: borane / tetrahydrofuran / 70 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / 5 h / 100 °C

3: XPhos; caesium carbonate; palladium diacetate / 1,4-dioxane / 90 °C / Inert atmosphere

4: sodium hydroxide / methanol / 10 h / 40 °C

With borane; palladium diacetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; XPhos; In tetrahydrofuran; 1,4-dioxane; methanol;

DOI:10.1016/j.ejmech.2019.111716

upstream raw materials:

N-[2-(aminomethyl)phenyl]-N-methylmethanesulfonamide

2,4-dichloro-7-p-methylbenzenesulfonyl-7H-pyrrole[2,3-d]pyrimidin-4-amine

2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine

N-(2-cyanophenyl)-N-methylmethanesulfonamide