(4aS,5S,7aS)-7a-(2,3-difluoro-5-nitrophenyl)-5-(difluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-amine

Base Information

Chemical Name:(4aS,5S,7aS)-7a-(2,3-difluoro-5-nitrophenyl)-5-(difluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-amine
CAS No.:1391001-83-4
Molecular Formula:C₁₃H₁₁F₄N₃O₃S
Molecular Weight:365.308
Hs Code.:

Synonyms:(4aS,5S,7aS)-7a-(2,3-difluoro-5-nitrophenyl)-5-(difluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-amine

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Chemical Property of (4aS,5S,7aS)-7a-(2,3-difluoro-5-nitrophenyl)-5-(difluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-amine

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Technology Process of (4aS,5S,7aS)-7a-(2,3-difluoro-5-nitrophenyl)-5-(difluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-amine

There total 17 articles about (4aS,5S,7aS)-7a-(2,3-difluoro-5-nitrophenyl)-5-(difluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1391001-82-3
(4aS,5S,7aS)-5-(difluoromethyl)-7a-(2,3-difluorophenyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-amine

: 1391001-83-4
(4aS,5S,7aS)-7a-(2,3-difluoro-5-nitrophenyl)-5-(difluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-amine

Guidance literature:: (4aS,5S,7aS)-5-(difluoromethyl)-7a-(2,3-difluorophenyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-amine; With sulfuric acid; nitric acid; trifluoroacetic acid; at 0 ℃; for 1.83333h;

With sodium hydrogencarbonate; In water; Saturated solution;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1391001-83-4
(4aS,5S,7aS)-7a-(2,3-difluoro-5-nitrophenyl)-5-(difluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-amine

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran;

Reference yield:

: 38573-88-5
1-bromo-2,3-difluorobenzene

: 1391001-83-4
(4aS,5S,7aS)-7a-(2,3-difluoro-5-nitrophenyl)-5-(difluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-amine

Guidance literature:: Multi-step reaction with 9 steps

1.1: n-butyllithium / toluene; hexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C

2.1: zinc; acetic acid / 0 - 20 °C

2.2: Saturated solution

3.1: dichloromethane / 18 h / 20 °C

4.1: trifluoromethylsulfonic anhydride; pyridine / dichloromethane / 1.5 h / 0 °C

5.1: hydrogenchloride; water / methanol

6.1: Dess-Martin periodane / dichloromethane / 0 - 20 °C

7.1: diethylamino-sulfur trifluoride / dichloromethane / 0 - 20 °C

8.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; methanol / 16 h / Reflux

9.1: nitric acid; trifluoroacetic acid; sulfuric acid / 1.83 h / 0 °C

9.2: Saturated solution

With pyridine; hydrogenchloride; methanol; n-butyllithium; trifluoromethylsulfonic anhydride; diethylamino-sulfur trifluoride; sulfuric acid; water; nitric acid; Dess-Martin periodane; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; zinc; In tetrahydrofuran; methanol; hexane; dichloromethane; toluene;