tert-butyl ((4aS,5S,7aS)-7a-(2,3-difluoro-5-nitrophenyl)-5-(difluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)carbamate

Base Information

Chemical Name:tert-butyl ((4aS,5S,7aS)-7a-(2,3-difluoro-5-nitrophenyl)-5-(difluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)carbamate
CAS No.:1391001-84-5
Molecular Formula:C₁₈H₁₉F₄N₃O₅S
Molecular Weight:465.426
Hs Code.:

Synonyms:tert-butyl ((4aS,5S,7aS)-7a-(2,3-difluoro-5-nitrophenyl)-5-(difluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)carbamate

Suppliers and Price of tert-butyl ((4aS,5S,7aS)-7a-(2,3-difluoro-5-nitrophenyl)-5-(difluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl ((4aS,5S,7aS)-7a-(2,3-difluoro-5-nitrophenyl)-5-(difluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl ((4aS,5S,7aS)-7a-(2,3-difluoro-5-nitrophenyl)-5-(difluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)carbamate

There total 18 articles about tert-butyl ((4aS,5S,7aS)-7a-(2,3-difluoro-5-nitrophenyl)-5-(difluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1391001-83-4
(4aS,5S,7aS)-7a-(2,3-difluoro-5-nitrophenyl)-5-(difluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-amine

: 1391001-84-5
tert-butyl ((4aS,5S,7aS)-7a-(2,3-difluoro-5-nitrophenyl)-5-(difluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)carbamate

Guidance literature:: In tetrahydrofuran; at 60 ℃;

Reference yield:

: 38573-88-5
1-bromo-2,3-difluorobenzene

: 1391001-84-5
tert-butyl ((4aS,5S,7aS)-7a-(2,3-difluoro-5-nitrophenyl)-5-(difluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)carbamate

Guidance literature:: Multi-step reaction with 10 steps

1.1: n-butyllithium / toluene; hexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C

2.1: zinc; acetic acid / 0 - 20 °C

2.2: Saturated solution

3.1: dichloromethane / 18 h / 20 °C

4.1: trifluoromethylsulfonic anhydride; pyridine / dichloromethane / 1.5 h / 0 °C

5.1: hydrogenchloride; water / methanol

6.1: Dess-Martin periodane / dichloromethane / 0 - 20 °C

7.1: diethylamino-sulfur trifluoride / dichloromethane / 0 - 20 °C

8.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; methanol / 16 h / Reflux

9.1: nitric acid; trifluoroacetic acid; sulfuric acid / 1.83 h / 0 °C

9.2: Saturated solution

10.1: tetrahydrofuran / 60 °C

With pyridine; hydrogenchloride; methanol; n-butyllithium; trifluoromethylsulfonic anhydride; diethylamino-sulfur trifluoride; sulfuric acid; water; nitric acid; Dess-Martin periodane; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; zinc; In tetrahydrofuran; methanol; hexane; dichloromethane; toluene;

Reference yield:

: 1388651-54-4
1-morpholino-2-(1-(trityloxy)but-3-en-2-yloxy)ethanone

: 1391001-84-5
tert-butyl ((4aS,5S,7aS)-7a-(2,3-difluoro-5-nitrophenyl)-5-(difluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)carbamate

Guidance literature:: Multi-step reaction with 13 steps

1.1: TurboGrignard / tetrahydrofuran / 0 - 10 °C / Inert atmosphere

1.2: 0 - 10 °C

2.1: hydroxylamine hydrochloride; sodium acetate / methanol / 20 - 35 °C

3.1: hydroquinone / toluene / 13 h / 110 - 115 °C

4.1: zinc; acetic acid / 15 - 18 °C

5.1: acetone / 0.25 h / 61.9 °C

6.1: sodium hydroxide / ethyl acetate; water / 1.7 - 5 °C

6.2: 1.5 h

7.1: trifluoromethylsulfonic anhydride; pyridine / dichloromethane / 1.5 h / 0 °C

8.1: hydrogenchloride; water / methanol

9.1: Dess-Martin periodane / dichloromethane / 0 - 20 °C

10.1: diethylamino-sulfur trifluoride / dichloromethane / 0 - 20 °C

11.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; methanol / 16 h / Reflux

12.1: nitric acid; trifluoroacetic acid; sulfuric acid / 1.83 h / 0 °C

12.2: Saturated solution

13.1: tetrahydrofuran / 60 °C

With pyridine; hydrogenchloride; methanol; TurboGrignard; trifluoromethylsulfonic anhydride; diethylamino-sulfur trifluoride; sulfuric acid; hydroxylamine hydrochloride; water; nitric acid; sodium acetate; Dess-Martin periodane; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; hydroquinone; trifluoroacetic acid; sodium hydroxide; zinc; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; acetone; toluene;