4-benzyloxy-2-(tert-butyloxycarbonylamino)-1-iodo-5,6,7,8-tetrahydronaphthalene

Base Information

Chemical Name:4-benzyloxy-2-(tert-butyloxycarbonylamino)-1-iodo-5,6,7,8-tetrahydronaphthalene
CAS No.:452921-69-6
Molecular Formula:C₂₂H₂₆INO₃
Molecular Weight:479.358
Hs Code.:

Synonyms:4-benzyloxy-2-(tert-butyloxycarbonylamino)-1-iodo-5,6,7,8-tetrahydronaphthalene

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Chemical Property of 4-benzyloxy-2-(tert-butyloxycarbonylamino)-1-iodo-5,6,7,8-tetrahydronaphthalene

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Technology Process of 4-benzyloxy-2-(tert-butyloxycarbonylamino)-1-iodo-5,6,7,8-tetrahydronaphthalene

There total 7 articles about 4-benzyloxy-2-(tert-butyloxycarbonylamino)-1-iodo-5,6,7,8-tetrahydronaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 452921-83-4
1-benzyloxy-3-(tert-butyloxycarbonylamino)-5,6,7,8-tetrahydronaphthalene

: 452921-69-6
4-benzyloxy-2-(tert-butyloxycarbonylamino)-1-iodo-5,6,7,8-tetrahydronaphthalene

Guidance literature:: With iodine; iodic acid; In methanol; water; at 65 ℃; for 1.5h;
DOI:10.1002/1099-0690(200205)2002:10<1634::AID-EJOC1634>3.0.CO;2-Y

Reference yield:

: 119-64-2
tetralin

: 452921-69-6
4-benzyloxy-2-(tert-butyloxycarbonylamino)-1-iodo-5,6,7,8-tetrahydronaphthalene

Guidance literature:: Multi-step reaction with 7 steps

1.1: 16 percent / HNO₃; H₂SO₄

2.1: 27 percent / SnCl₂; HCl; HOAc / ethanol / 5 h

3.1: NaNO₂; H₂SO₄ / H₂O / 1 h / -5 °C

3.2: 54 percent / H₂O / -5 - 60 °C

4.1: 97 percent / K₂CO₃; tetrabutylammonium iodide / acetone; dimethylformamide / 14 h / 20 °C

5.1: 100 percent / H₂ / PtO₂*H₂O / dioxane / 24 h / 2250.23 Torr

6.1: 82 percent / dioxane / 24 h / 20 °C

7.1: 94 percent / I₂; HIO₃ / methanol; H₂O / 1.5 h / 65 °C

With hydrogenchloride; sulfuric acid; hydrogen; iodine; nitric acid; iodic acid; tetra-(n-butyl)ammonium iodide; potassium carbonate; acetic acid; tin(ll) chloride; sodium nitrite; platinum(IV) oxide; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; acetone;
DOI:10.1002/1099-0690(200205)2002:10<1634::AID-EJOC1634>3.0.CO;2-Y

Reference yield:

: 50536-99-7
3-nitro-5,6,7,8-tetrahydro-[1]naphthylamine

: 452921-69-6
4-benzyloxy-2-(tert-butyloxycarbonylamino)-1-iodo-5,6,7,8-tetrahydronaphthalene

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaNO₂; H₂SO₄ / H₂O / 1 h / -5 °C

1.2: 54 percent / H₂O / -5 - 60 °C

2.1: 97 percent / K₂CO₃; tetrabutylammonium iodide / acetone; dimethylformamide / 14 h / 20 °C

3.1: 100 percent / H₂ / PtO₂*H₂O / dioxane / 24 h / 2250.23 Torr

4.1: 82 percent / dioxane / 24 h / 20 °C

5.1: 94 percent / I₂; HIO₃ / methanol; H₂O / 1.5 h / 65 °C

With sulfuric acid; hydrogen; iodine; iodic acid; tetra-(n-butyl)ammonium iodide; potassium carbonate; sodium nitrite; platinum(IV) oxide; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; acetone;
DOI:10.1002/1099-0690(200205)2002:10<1634::AID-EJOC1634>3.0.CO;2-Y