5,7-dinitro-1,2,3,4-tetrahydronaphthalene

Base Information

• Chemical Name: 5,7-dinitro-1,2,3,4-tetrahydronaphthalene
• CAS No.: 51522-30-6
• Molecular Formula: C₁₀H₁₀N₂O₄
• Molecular Weight: 222.2
• Mol file: 51522-30-6.mol

Synonyms:5,7-dinitro-1,2,3,4-tetrahydronaphthalene

Chemical Property of 5,7-dinitro-1,2,3,4-tetrahydronaphthalene

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

5,7-dinitro-1,2,3,4-tetrahydronaphthalene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,7-dinitro-1,2,3,4-tetrahydronaphthalene

There total 3 articles about 5,7-dinitro-1,2,3,4-tetrahydronaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

tetralin (119-64-2) → 5,7-dinitro-1,2,3,4-tetrahydronaphthalene (51522-30-6)

Guidance literature:

With sulfuric acid; nitric acid; at 0 ℃; for 0.5h;

Reference yield:

α-naphthol (90-15-3) → 5,7-dinitro-1,2,3,4-tetrahydronaphthalene (51522-30-6)

Guidance literature:

Multi-step reaction with 2 steps

1: nickel / 200 °C / Hydrogenation

2: sulfuric acid; nitric acid / <40

With sulfuric acid; nitric acid; nickel;

Reference yield:

→ 5,7-dinitro-1,2,3,4-tetrahydronaphthalene (51522-30-6)

Guidance literature:

Dichlorethan 1, NaOAc, Enamin 3a;

upstream raw materials:

tetralin

α-naphthol

Downstream raw materials:

2-((2-((3-amino-5,6,7,8-tetrahydronaphthalen-1-yl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide

2-((5-chloro-2-((3-nitro-5,6,7,8-tetrahydronaphthalen-1-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

3,5-dinitrophthalic acid

2,4-dinitronaphthalene

Refernces

• 1、 Tietze, Lutz F.,Herzig, Tobias,Feuerstein, Tim,Schuberth, Ingrid. "Synthesis and biological evaluation of novel analogues and prodrugs of the cytotoxic antibiotic CC-1065 for selective cancer therapy". . p. 1634 - 1645. Retrieved 2007/10/03.