5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl](tetrahydropyran-4-yl)amide

Base Information

Chemical Name:5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl](tetrahydropyran-4-yl)amide
CAS No.:1616924-76-5
Molecular Formula:C₃₇H₅₁N₃O₅Si
Molecular Weight:645.915
Hs Code.:

5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl](tetrahydropyran-4-yl)amide

Synonyms:5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl](tetrahydropyran-4-yl)amide

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Chemical Property of 5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl](tetrahydropyran-4-yl)amide

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Technology Process of 5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl](tetrahydropyran-4-yl)amide

There total 14 articles about 5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl](tetrahydropyran-4-yl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.53%

: 1616922-83-8
5-(benzyloxy)-6-hydroxy-2-((1-phenylcyclopentyl)methyl)pyrimidine-4-carboxylic acid

: 1616924-75-4
[2-(tert-butyldimethylsilanyloxy)ethyl](tetrahydropyran-4-yl)amine

: 1616924-76-5
5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl](tetrahydropyran-4-yl)amide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 101711-55-1
2‐((tert‐butyldimethylsilyl)oxy)ethan‐1‐amine

: 1616924-76-5
5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl](tetrahydropyran-4-yl)amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol / 1 h / 20 °C / Cooling

1.2: 20 h / 20 °C / Cooling

2.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 5407-84-1
β-phenyl-β,β-tetramethylenepropionitrile

: 1616924-76-5
5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl](tetrahydropyran-4-yl)amide

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium chloride; trimethylaluminum / toluene / 14 h / 5 - 80 °C

2: sodium methylate / methanol / 16 h / 0 - 20 °C

3: lithium hydroxide monohydrate / tetrahydrofuran; water / 18 h / Reflux

4: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C

With lithium hydroxide monohydrate; trimethylaluminum; sodium methylate; ammonium chloride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;