4-(5-ethyl pyrimidin-2-yloxy)-N-(4-(4-(methylsulfonyl)piperazin-1-yl)-4-oxo butyl)cyclohexanecarboxamide

Base Information

Chemical Name:4-(5-ethyl pyrimidin-2-yloxy)-N-(4-(4-(methylsulfonyl)piperazin-1-yl)-4-oxo butyl)cyclohexanecarboxamide
CAS No.:1361392-19-9
Molecular Formula:C₂₂H₃₅N₅O₅S
Molecular Weight:481.616
Hs Code.:

Synonyms:4-(5-ethyl pyrimidin-2-yloxy)-N-(4-(4-(methylsulfonyl)piperazin-1-yl)-4-oxo butyl)cyclohexanecarboxamide

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Chemical Property of 4-(5-ethyl pyrimidin-2-yloxy)-N-(4-(4-(methylsulfonyl)piperazin-1-yl)-4-oxo butyl)cyclohexanecarboxamide

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Technology Process of 4-(5-ethyl pyrimidin-2-yloxy)-N-(4-(4-(methylsulfonyl)piperazin-1-yl)-4-oxo butyl)cyclohexanecarboxamide

There total 2 articles about 4-(5-ethyl pyrimidin-2-yloxy)-N-(4-(4-(methylsulfonyl)piperazin-1-yl)-4-oxo butyl)cyclohexanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1361392-17-7
4-(5-ethylpyrimidin-2-yloxy)cyclohexanecarboxylic acid

: 1361392-21-3
4-amino-1-(4-(methylsulfonyl)piperazin-1-yl)butan-1-one hydrochloride

: 1361392-19-9
4-(5-ethyl pyrimidin-2-yloxy)-N-(4-(4-(methylsulfonyl)piperazin-1-yl)-4-oxo butyl)cyclohexanecarboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield:

: 3685-22-1,3685-26-5,17419-81-7
4-hydroxycyclohexanecarboxylic acid

: 1361392-19-9
4-(5-ethyl pyrimidin-2-yloxy)-N-(4-(4-(methylsulfonyl)piperazin-1-yl)-4-oxo butyl)cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / 2,4-dichlorophenoxyacetic acid dimethylamine; mineral oil / 0.5 h / 0 - 20 °C

1.2: 15 h / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 12 h / 20 °C

With sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 2,4-dichlorophenoxyacetic acid dimethylamine; N,N-dimethyl-formamide; mineral oil;