TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID

Base Information

• Chemical Name: TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID
• CAS No.: 3685-22-1
• Molecular Formula: C7H12O3
• Molecular Weight: 144.17
• Hs Code.: 2918199890
• Mol file: 3685-22-1.mol

Synonyms:cis-4-Hydroxycyclohexanecarboxylic acid;cis-4-Hydroxycyclohexane-1-carboxylicacid;

Chemical Property of TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 150 °C
• Refractive Index: 1.523
• Boiling Point: 307.898 °C at 760 mmHg
• PKA: pK1:4.836 (25°C)
• Flash Point: 154.234 °C
• PSA: 57.53000
• Density: 1.246 g/cm³
• LogP: 0.62210
• Storage Temp.: 2-8°C
• Solubility.: almost transparency in Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

trans-4-Hydroxycyclohexanecarboxylic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 36/37/38-25
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID

There total 25 articles about TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-hydroxy-benzoic acid (99-96-7) → 4-hydroxycyclohexanecarboxylic acid (3685-22-1,3685-26-5,17419-81-7)

Guidance literature:

With Rh/Al₂O₃; hydrogen; In methanol; at 20 ℃;

DOI:10.2298/JSC150430063O

Reference yield: 96.0%

ethyl (1s,4s)-4-hydroxycyclohexanecarboxylate (75877-66-6) → cis-4-hydroxycyclohexanecarboxylic acid (3685-26-5,17419-81-7,3685-22-1)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 7h;

DOI:10.1016/j.chempr.2019.03.010

Reference yield: 90.0%

methyl 4-hydroxycyclohexanecarboxylate (3618-03-9,6125-57-1,17449-76-2) → 4-hydroxycyclohexanecarboxylic acid (3685-22-1,3685-26-5,17419-81-7)

Guidance literature:

With methanol; sodium hydroxide; at 20 ℃; Cooling with ice;

upstream raw materials:

4-oxocyclohexanecarboxylic acid

4-hydroxy-benzoic acid

4-hydroxycyclohexyl carboxylic acid ethyl ester

water

Downstream raw materials:

2-oxa-bicyclo[2.2.2]octan-3-one

cis-4-hydroxy-cyclohexanecarboxylic acid phenacyl ester

cis-4-acetoxy-cyclohexanecarboxylic acid

4-heptyloxycyclohexane carboxylic acid

Refernces

• 1、 Zhong, Rui,Wei, Zeyuan,Zhang, Wei,Liu, Shun,Liu, Qiang. "A Practical and Stereoselective In Situ NHC-Cobalt Catalytic System for Hydrogenation of Ketones and Aldehydes". supporting information. p. 1552 - 1566. Retrieved 2019/06/14.
• 2、 -. "DOPAMINE D3 RECEPTOR ANTAGONISTS HAVING A BICYCLO MOIETY". Paragraph 1087; 1088. . Retrieved 2017/02/28.