3-[2,6-diamino-5-(4-nitro-phenyl)-pyrimidin-4-yl]-propionic acid methyl ester

Base Information

Chemical Name:3-[2,6-diamino-5-(4-nitro-phenyl)-pyrimidin-4-yl]-propionic acid methyl ester
CAS No.:848666-40-0
Molecular Formula:C₁₄H₁₅N₅O₄
Molecular Weight:317.304
Hs Code.:

Synonyms:3-[2,6-diamino-5-(4-nitro-phenyl)-pyrimidin-4-yl]-propionic acid methyl ester

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Chemical Property of 3-[2,6-diamino-5-(4-nitro-phenyl)-pyrimidin-4-yl]-propionic acid methyl ester

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Technology Process of 3-[2,6-diamino-5-(4-nitro-phenyl)-pyrimidin-4-yl]-propionic acid methyl ester

There total 2 articles about 3-[2,6-diamino-5-(4-nitro-phenyl)-pyrimidin-4-yl]-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 848665-64-5
2-(4-nitrophenyl)-3-oxopentanenitrile

: 50-01-1
guanidine hydrochloride

: 848666-40-0
3-[2,6-diamino-5-(4-nitro-phenyl)-pyrimidin-4-yl]-propionic acid methyl ester

Guidance literature:: 2-(4-nitrophenyl)-3-oxopentanenitrile; With diazomethyl-trimethyl-silane; In methanol; diethyl ether; at 0 ℃;

guanidine hydrochloride; With potassium chloride; sodium methylate; In tetrahydrofuran; methanol; for 0.25h; Heating / reflux;

Reference yield: 11.0%

: 50-01-1
guanidine hydrochloride

: 555-21-5,34512-13-5,174848-08-9
4-Nitrophenylacetonitrile

: 1490-25-1
succinic acid monomethylester chloride

: 848666-40-0
3-[2,6-diamino-5-(4-nitro-phenyl)-pyrimidin-4-yl]-propionic acid methyl ester

Guidance literature:: 4-Nitrophenylacetonitrile; succinic acid monomethylester chloride; With dmap; triethylamine; In dichloromethane; at 0 ℃; for 1.01667h;

With diazomethyl-trimethyl-silane; In methanol; diethyl ether; dichloromethane; at 0 ℃;

guanidine hydrochloride; With potassium chloride; sodium methylate; In tetrahydrofuran; methanol; for 0.25h; Heating / reflux;