5-(cyclohexylmethylamino)-3-ethoxycarbonylmethoxythieno[3,2-b][1]benzothiophene-2-carboxylic acid methyl ester

Base Information

Chemical Name:5-(cyclohexylmethylamino)-3-ethoxycarbonylmethoxythieno[3,2-b][1]benzothiophene-2-carboxylic acid methyl ester
CAS No.:881034-10-2
Molecular Formula:C₂₃H₂₇NO₅S₂
Molecular Weight:461.603
Hs Code.:

Synonyms:5-(cyclohexylmethylamino)-3-ethoxycarbonylmethoxythieno[3,2-b][1]benzothiophene-2-carboxylic acid methyl ester

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Chemical Property of 5-(cyclohexylmethylamino)-3-ethoxycarbonylmethoxythieno[3,2-b][1]benzothiophene-2-carboxylic acid methyl ester

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Technology Process of 5-(cyclohexylmethylamino)-3-ethoxycarbonylmethoxythieno[3,2-b][1]benzothiophene-2-carboxylic acid methyl ester

There total 10 articles about 5-(cyclohexylmethylamino)-3-ethoxycarbonylmethoxythieno[3,2-b][1]benzothiophene-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 881034-09-9
5-amino-3-ethoxycarbonylmethoxythieno[3,2-b][1]benzothiophene-2-carboxylic acid methyl ester

: 2043-61-0
cyclohexanecarbaldehyde

: 881034-10-2
5-(cyclohexylmethylamino)-3-ethoxycarbonylmethoxythieno[3,2-b][1]benzothiophene-2-carboxylic acid methyl ester

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 2h;
DOI:10.1016/j.bmc.2005.11.005

Reference yield:

: 145219-22-3
2-nitroisophthalic acid diallyl ester

: 881034-10-2
5-(cyclohexylmethylamino)-3-ethoxycarbonylmethoxythieno[3,2-b][1]benzothiophene-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 100 percent / DBU / dimethylformamide / 1 h

2.1: 79 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

3.1: Et₃N / dimethylformamide / 16 h / 20 °C

3.2: 100 percent / NaH / dimethylformamide / 0.5 h

4.1: 100 percent / K₂CO₃ / dimethylformamide / 2 h / 20 °C

5.1: 68 percent / AcOH / Pd(PPh₃)4 / tetrahydrofuran / 2 h / 20 °C

6.1: 62 percent / diphenylphosphoryl azide; triethylamine / toluene / 16 h / 100 °C

7.1: 100 percent / CF₃CO₂H / CH₂Cl₂ / 4 h / 0 - 20 °C

8.1: 57 percent / NaBH(OAc)3; AcOH / 1,2-dichloro-ethane / 2 h / 20 °C

With diphenylphosphoranyl azide; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; 6.1: Curtius rearrangement;
DOI:10.1016/j.bmc.2005.11.005

Reference yield:

: 892128-04-0
3-hydroxybenzo[b]thiophene-2,7-dicarboxylic acid 7-allyl ester 2-methyl ester

: 881034-10-2
5-(cyclohexylmethylamino)-3-ethoxycarbonylmethoxythieno[3,2-b][1]benzothiophene-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 79 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

2.1: Et₃N / dimethylformamide / 16 h / 20 °C

2.2: 100 percent / NaH / dimethylformamide / 0.5 h

3.1: 100 percent / K₂CO₃ / dimethylformamide / 2 h / 20 °C

4.1: 68 percent / AcOH / Pd(PPh₃)4 / tetrahydrofuran / 2 h / 20 °C

5.1: 62 percent / diphenylphosphoryl azide; triethylamine / toluene / 16 h / 100 °C

6.1: 100 percent / CF₃CO₂H / CH₂Cl₂ / 4 h / 0 - 20 °C

7.1: 57 percent / NaBH(OAc)3; AcOH / 1,2-dichloro-ethane / 2 h / 20 °C

With diphenylphosphoranyl azide; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; triethylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; 5.1: Curtius rearrangement;
DOI:10.1016/j.bmc.2005.11.005