Technology Process of methyl 5-[(3aS,4S,6aR)-1,3-bis(4-methoxybenzyl)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoate
There total 1 articles about methyl 5-[(3aS,4S,6aR)-1,3-bis(4-methoxybenzyl)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
biotin methyl ester;
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
at 0 ℃;
for 0.333333h;
Inert atmosphere;
p-methoxybenzyl chloride;
In
N,N-dimethyl-formamide; mineral oil;
at 0 - 20 ℃;
Product distribution / selectivity;
- Guidance literature:
-
methyl 5-[(3aS,4S,6aR)-1,3-bis(4-methoxybenzyl)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoate;
With
water; lithium hydroxide;
In
tetrahydrofuran; methanol;
at 0 - 20 ℃;
With
hydrogenchloride;
In
water;
pH=2;
- Guidance literature:
-
methyl 5-[(3aS,4S,6aR)-1,3-bis(4-methoxybenzyl)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoate;
With
potassium hexamethylsilazane;
In
tetrahydrofuran;
at -78 ℃;
for 0.5h;
Inert atmosphere;
With
2,4,6-Triisopropylbenzenesulfonyl azide;
In
tetrahydrofuran;
at -78 ℃;
for 1h;
With
acetic acid;
In
tetrahydrofuran;
at 20 ℃;
for 3h;
Product distribution / selectivity;