methyl 5-[(3aS,4S,6aR)-1,3-bis(4-methoxybenzyl)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoate

Base Information

Chemical Name:methyl 5-[(3aS,4S,6aR)-1,3-bis(4-methoxybenzyl)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoate
CAS No.:1245507-44-1
Molecular Formula:C₂₇H₃₄N₂O₅S
Molecular Weight:498.643
Hs Code.:

Synonyms:methyl 5-[(3aS,4S,6aR)-1,3-bis(4-methoxybenzyl)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoate

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Chemical Property of methyl 5-[(3aS,4S,6aR)-1,3-bis(4-methoxybenzyl)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoate

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Technology Process of methyl 5-[(3aS,4S,6aR)-1,3-bis(4-methoxybenzyl)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoate

There total 1 articles about methyl 5-[(3aS,4S,6aR)-1,3-bis(4-methoxybenzyl)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 824-94-2
p-methoxybenzyl chloride

: 608-16-2
biotin methyl ester

: 1245507-44-1
methyl 5-[(3aS,4S,6aR)-1,3-bis(4-methoxybenzyl)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoate

Guidance literature:: biotin methyl ester; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.333333h; Inert atmosphere;

p-methoxybenzyl chloride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; Product distribution / selectivity;

Reference yield: 91.0%

: 1245507-44-1
methyl 5-[(3aS,4S,6aR)-1,3-bis(4-methoxybenzyl)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoate

: 1245507-48-5
N,N'-p-methoxybenzylbiotin

Guidance literature:: methyl 5-[(3aS,4S,6aR)-1,3-bis(4-methoxybenzyl)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoate; With water; lithium hydroxide; In tetrahydrofuran; methanol; at 0 - 20 ℃;

With hydrogenchloride; In water; pH=2;

Reference yield: 67.0%

: 1245507-44-1
methyl 5-[(3aS,4S,6aR)-1,3-bis(4-methoxybenzyl)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoate

: 1245507-45-2
N,N'-p-methoxybenzyl-2-azidobiotin methyl ester

Guidance literature:: methyl 5-[(3aS,4S,6aR)-1,3-bis(4-methoxybenzyl)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoate; With potassium hexamethylsilazane; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

With 2,4,6-Triisopropylbenzenesulfonyl azide; In tetrahydrofuran; at -78 ℃; for 1h;

With acetic acid; In tetrahydrofuran; at 20 ℃; for 3h; Product distribution / selectivity;