7,16-bis(5-chloro-2-hydroxy-3-trifluoroacetamidobenzyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane

Base Information

Chemical Name:7,16-bis(5-chloro-2-hydroxy-3-trifluoroacetamidobenzyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane
CAS No.:227796-00-1
Molecular Formula:C₃₀H₃₆Cl₂F₆N₄O₈
Molecular Weight:765.534
Hs Code.:

Synonyms:7,16-bis(5-chloro-2-hydroxy-3-trifluoroacetamidobenzyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane

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Chemical Property of 7,16-bis(5-chloro-2-hydroxy-3-trifluoroacetamidobenzyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane

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Technology Process of 7,16-bis(5-chloro-2-hydroxy-3-trifluoroacetamidobenzyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane

There total 3 articles about 7,16-bis(5-chloro-2-hydroxy-3-trifluoroacetamidobenzyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 93416-35-4
N-(5-chloro-2-hydroxyphenyl)trifluoroacetamide

: 23978-55-4
1,4,10,13-tetraoxa-7,16-diazacyclooctadecane

: 227796-00-1
7,16-bis(5-chloro-2-hydroxy-3-trifluoroacetamidobenzyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane

Guidance literature:: In benzene; at 80 ℃; for 20h;
DOI:10.1021/jo9816212

Reference yield:

: 95-85-2
2-hydroxy-5-chloro-aniline

: 227796-00-1
7,16-bis(5-chloro-2-hydroxy-3-trifluoroacetamidobenzyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 24 h / Ambient temperature

2: K₂CO₃ / methanol / 5 h / Ambient temperature

3: 64 percent / benzene / 20 h / 80 °C

With potassium carbonate; In pyridine; methanol; benzene;
DOI:10.1021/jo9816212

Reference yield:

: trifluoro-acetic acid 4-chloro-2-(2,2,2-trifluoro-acetylamino)-phenyl ester

: 227796-00-1
7,16-bis(5-chloro-2-hydroxy-3-trifluoroacetamidobenzyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane

Guidance literature:: Multi-step reaction with 2 steps

1: K₂CO₃ / methanol / 5 h / Ambient temperature

2: 64 percent / benzene / 20 h / 80 °C

With potassium carbonate; In methanol; benzene;
DOI:10.1021/jo9816212