(S)-3-{3-[(S)-1-(tert-Butyl-dimethyl-silanyloxy)-propyl]-phenyl}-2-methyl-propionaldehyde

Base Information

Chemical Name:(S)-3-{3-[(S)-1-(tert-Butyl-dimethyl-silanyloxy)-propyl]-phenyl}-2-methyl-propionaldehyde
CAS No.:594855-02-4
Molecular Formula:C₁₉H₃₂O₂Si
Molecular Weight:320.547
Hs Code.:

Synonyms:(S)-3-{3-[(S)-1-(tert-Butyl-dimethyl-silanyloxy)-propyl]-phenyl}-2-methyl-propionaldehyde

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Chemical Property of (S)-3-{3-[(S)-1-(tert-Butyl-dimethyl-silanyloxy)-propyl]-phenyl}-2-methyl-propionaldehyde

Chemical Property:

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Technology Process of (S)-3-{3-[(S)-1-(tert-Butyl-dimethyl-silanyloxy)-propyl]-phenyl}-2-methyl-propionaldehyde

There total 8 articles about (S)-3-{3-[(S)-1-(tert-Butyl-dimethyl-silanyloxy)-propyl]-phenyl}-2-methyl-propionaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 594854-62-3
(S)-3-{3-[(S)-1-(tert-Butyl-dimethyl-silanyloxy)-propyl]-phenyl}-2-methyl-propan-1-ol

: 594855-02-4
(S)-3-{3-[(S)-1-(tert-Butyl-dimethyl-silanyloxy)-propyl]-phenyl}-2-methyl-propionaldehyde

Guidance literature:: With oxalyl dichloride; TEA; dimethyl sulfoxide; In dichloromethane;
DOI:10.1248/cpb.52.163

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 594855-02-4
(S)-3-{3-[(S)-1-(tert-Butyl-dimethyl-silanyloxy)-propyl]-phenyl}-2-methyl-propionaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1: 61 percent / imidazole / dimethylformamide

2: 92 percent / NaBH₄ / ethanol

3: 95 percent / NaH / tetrahydrofuran

4: 94 percent / n-Bu₃SnH / toluene

5: 70 percent / aq. p-TsOH / ethanol

6: 96 percent / (COCl)2; DMSO; TEA / CH₂Cl₂

With 1H-imidazole; sodium tetrahydroborate; oxalyl dichloride; TEA; tri-n-butyl-tin hydride; sodium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 6: Swern oxidation;
DOI:10.1248/cpb.52.163

Reference yield:

: 224622-38-2
(S)-1-(3'-bromophenyl)-1-propanol

: 594855-02-4
(S)-3-{3-[(S)-1-(tert-Butyl-dimethyl-silanyloxy)-propyl]-phenyl}-2-methyl-propionaldehyde

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-BuLi / tetrahydrofuran

1.2: 100 percent / tetrahydrofuran

2.1: 61 percent / imidazole / dimethylformamide

3.1: 92 percent / NaBH₄ / ethanol

4.1: 95 percent / NaH / tetrahydrofuran

5.1: 94 percent / n-Bu₃SnH / toluene

6.1: 70 percent / aq. p-TsOH / ethanol

7.1: 96 percent / (COCl)2; DMSO; TEA / CH₂Cl₂

With 1H-imidazole; sodium tetrahydroborate; n-butyllithium; oxalyl dichloride; TEA; tri-n-butyl-tin hydride; sodium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 7.1: Swern oxidation;
DOI:10.1248/cpb.52.163