5-METHOXY-1H-BENZOIMIDAZOLE-2-CARBOXYLICACID

Base Information

• Chemical Name: 5-METHOXY-1H-BENZOIMIDAZOLE-2-CARBOXYLICACID
• CAS No.: 887572-60-3
• Molecular Formula: C9H8N2O3
• Molecular Weight: 192.1714
• Hs Code.: 2933990090
• Mol file: 887572-60-3.mol

Synonyms:1H-Benzimidazole-2-carboxylicacid, 5-methoxy- (9CI);5-Methoxy-1H-benzimidazole-2-carboxylic acid;

Chemical Property of 5-METHOXY-1H-BENZOIMIDAZOLE-2-CARBOXYLICACID

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 152-154℃ (ethanol )
• Refractive Index: 1.689
• Boiling Point: 468.8 °C at 760 mmHg
• Flash Point: 237.322 °C
• PSA: 75.21000
• Density: 1.46 g/cm³
• LogP: 1.26970

Purity/Quality:

97% ^*data from raw suppliers

6-methoxy-1H-benzo[d]imidazole-2-carboxylicacid 95%-98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-METHOXY-1H-BENZOIMIDAZOLE-2-CARBOXYLICACID

There total 4 articles about 5-METHOXY-1H-BENZOIMIDAZOLE-2-CARBOXYLICACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(5-methoxy-1H-benzimidazole-2-yl)-methanol (20033-99-2) → 5-methoxy-1H-benzo[d]imidazole-2-carboxylic acid (887572-60-3)

Guidance literature:

With potassium permanganate;

DOI:10.3390/molecules200815206

Reference yield:

5-methoxy-1H-benzoimidazole-2-carboxylic acid methyl ester (1016163-41-9) → 5-methoxy-1H-benzo[d]imidazole-2-carboxylic acid (887572-60-3)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; water; at 160 ℃; for 4h; microwave irradiation;

DOI:10.1021/jm701344b

Reference yield:

4-methoxyphenylene-1,2-diamine dihydrochloride (59548-39-9) + trifluoroacetic acid (76-05-1) → 5-methoxy-1H-benzo[d]imidazole-2-carboxylic acid (887572-60-3)

Guidance literature:

4-methoxyphenylene-1,2-diamine dihydrochloride; trifluoroacetic acid; at 80 ℃;

With sodium hydroxide; In 1,4-dioxane; at 200 ℃; Further stages.; microwave irradiation;

DOI:10.1016/j.bmcl.2007.09.043

upstream raw materials:

4-methoxyphenylene-1,2-diamine dihydrochloride

trifluoroacetic acid

(5-methoxy-1H-benzimidazole-2-yl)-methanol

5-methoxy-1H-benzoimidazole-2-carboxylic acid methyl ester

Downstream raw materials:

6-hydroxy-1H-benzimidazole-2-carboxylic acid

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