tert-butyl 4-[4-({[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]oxy}methyl)benzylidene]piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-[4-({[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]oxy}methyl)benzylidene]piperidine-1-carboxylate
CAS No.:1425971-11-4
Molecular Formula:C₂₃H₂₈F₃N₃O₃
Molecular Weight:451.489
Hs Code.:

Synonyms:tert-butyl 4-[4-({[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]oxy}methyl)benzylidene]piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-[4-({[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]oxy}methyl)benzylidene]piperidine-1-carboxylate

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Technology Process of tert-butyl 4-[4-({[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]oxy}methyl)benzylidene]piperidine-1-carboxylate

There total 3 articles about tert-butyl 4-[4-({[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]oxy}methyl)benzylidene]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1425970-71-3
tert-butyl 4-(4-(bromomethyl)benzylidene)piperidine-1-carboxylate

: 122431-37-2
2-methyl-5-trifluoromethyl-2H-pyrazol-3-ol

: 1425971-11-4
tert-butyl 4-[4-({[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]oxy}methyl)benzylidene]piperidine-1-carboxylate

Guidance literature:: 2-methyl-5-trifluoromethyl-2H-pyrazol-3-ol; With potassium hexamethylsilazane; In N,N-dimethyl-formamide; toluene; at 0 ℃; for 1h; Inert atmosphere;

tert-butyl 4-(4-(bromomethyl)benzylidene)piperidine-1-carboxylate; at 0 - 20 ℃; for 21h;

Reference yield:

: 1425970-70-2
tert-butyl 4-(4-(hydroxymethyl)benzylidene)piperidine-1-carboxylate

: 1425971-11-4
tert-butyl 4-[4-({[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]oxy}methyl)benzylidene]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 20 h / 20 °C

2.1: potassium hexamethylsilazane / N,N-dimethyl-formamide; toluene / 1 h / 0 °C / Inert atmosphere

2.2: 21 h / 0 - 20 °C

With carbon tetrabromide; potassium hexamethylsilazane; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 726185-65-5
tert-butyl 4-[4-(ethoxycarbonyl)benzylidene]piperidine-1-carboxylate

: 1425971-11-4
tert-butyl 4-[4-({[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]oxy}methyl)benzylidene]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 20 h / 20 °C

3.1: potassium hexamethylsilazane / N,N-dimethyl-formamide; toluene / 1 h / 0 °C / Inert atmosphere

3.2: 21 h / 0 - 20 °C

With lithium aluminium tetrahydride; carbon tetrabromide; potassium hexamethylsilazane; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;