2-tert-butyl 3-methyl 8-bromo-4-oxo-3,4-dihydroisoquinoline-2,3(1H)-dicarboxylate

Base Information

Chemical Name:2-tert-butyl 3-methyl 8-bromo-4-oxo-3,4-dihydroisoquinoline-2,3(1H)-dicarboxylate
CAS No.:1432514-81-2
Molecular Formula:C₁₆H₁₈BrNO₅
Molecular Weight:384.227
Hs Code.:

Synonyms:2-tert-butyl 3-methyl 8-bromo-4-oxo-3,4-dihydroisoquinoline-2,3(1H)-dicarboxylate

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Chemical Property of 2-tert-butyl 3-methyl 8-bromo-4-oxo-3,4-dihydroisoquinoline-2,3(1H)-dicarboxylate

Chemical Property:

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Technology Process of 2-tert-butyl 3-methyl 8-bromo-4-oxo-3,4-dihydroisoquinoline-2,3(1H)-dicarboxylate

There total 1 articles about 2-tert-butyl 3-methyl 8-bromo-4-oxo-3,4-dihydroisoquinoline-2,3(1H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 31954-27-5
N-(tert-butoxycarbonyl)glycine methyl ester

: 337536-14-8
methyl 3-bromo-2-(bromomethyl)benzoate

: 1432514-81-2
2-tert-butyl 3-methyl 8-bromo-4-oxo-3,4-dihydroisoquinoline-2,3(1H)-dicarboxylate

Guidance literature:: N-(tert-butoxycarbonyl)glycine methyl ester; With potassium tert-butylate; In N,N-dimethyl-formamide; at 18 - 25 ℃; for 0.0166667h;

methyl 3-bromo-2-(bromomethyl)benzoate; In N,N-dimethyl-formamide; at 18 - 25 ℃; for 3h;

Reference yield:

: 1432514-81-2
2-tert-butyl 3-methyl 8-bromo-4-oxo-3,4-dihydroisoquinoline-2,3(1H)-dicarboxylate

: 1607485-88-0
tert-butyl 8-((6-(N-(2,4-dimethoxybenzyl)-N-(6-fluoropyridin-2-yl)sulfamoyl)-5-fluoro-2-oxobenzo[d]oxazol-3(2H)-yl)methyl)-4-fluoro-3,4-dihydroisoquinoline-2(1H)carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogenchloride / 1,4-dioxane; water / 90 °C

2: N-ethyl-N,N-diisopropylamine / ethanol / 0.75 h / 20 °C / Sealed tube

3: sodium tetrahydroborate / tetrahydrofuran / 0.17 h / 20 °C / Sealed tube

4: diethylamino-sulfur trifluoride / dichloromethane / 0.08 h / -78 °C / Sealed tube; Inert atmosphere

5: palladium diacetate; 1,3-bis-(diphenylphosphino)propane; triethylamine / dimethyl sulfoxide / 22 h / 80 °C / Inert atmosphere

6: diisobutylaluminium hydride / tetrahydrofuran / 0.5 h / -78 - 20 °C / Inert atmosphere

7: di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 0.17 h / 20 °C / Sealed tube

With hydrogenchloride; sodium tetrahydroborate; diethylamino-sulfur trifluoride; di-tert-butyl-diazodicarboxylate; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; diisobutylaluminium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; dimethyl sulfoxide;