tert-butyl [(2R,3S,5R)-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-1-(trifluoroacetyl)piperidin-3-yl]carbamate

Base Information

Chemical Name:tert-butyl [(2R,3S,5R)-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-1-(trifluoroacetyl)piperidin-3-yl]carbamate
CAS No.:1280211-13-3
Molecular Formula:C₂₄H₂₈F₅N₅O₅S
Molecular Weight:593.575
Hs Code.:

tert-butyl [(2R,3S,5R)-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-1-(trifluoroacetyl)piperidin-3-yl]carbamate

Synonyms:tert-butyl [(2R,3S,5R)-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-1-(trifluoroacetyl)piperidin-3-yl]carbamate

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Chemical Property of tert-butyl [(2R,3S,5R)-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-1-(trifluoroacetyl)piperidin-3-yl]carbamate

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Technology Process of tert-butyl [(2R,3S,5R)-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-1-(trifluoroacetyl)piperidin-3-yl]carbamate

There total 9 articles about tert-butyl [(2R,3S,5R)-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-1-(trifluoroacetyl)piperidin-3-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1280210-88-9
tert-butyl {(2R,3S,5R)-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]piperidin-3-yl}carbamate

: 407-25-0
trifluoroacetic anhydride

: 1280211-13-3
tert-butyl [(2R,3S,5R)-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-1-(trifluoroacetyl)piperidin-3-yl]carbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield:

: 2646-90-4
2,5-difluorobenzaldehyde

: 1280211-13-3
tert-butyl [(2R,3S,5R)-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-1-(trifluoroacetyl)piperidin-3-yl]carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonium acetate / ethanol / 16 h / Reflux

2.1: sodium tetrahydroborate / nickel (II) chloride hexahydrate / methanol / 1 h / 0 °C

2.2: 15 h / 0 - 20 °C

3.1: N,N,N,N,-tetramethylethylenediamine; trimethylsilyl iodide / dichloromethane / 2 h / 0 °C

3.2: 3 h

3.3: 0.17 h

4.1: N,N,N,N,-tetramethylethylenediamine / dichloromethane; N,N-dimethyl-formamide / 64 h / 20 °C

5.1: dimethylsulfide borane complex / tetrahydrofuran / 1.25 h / 70 °C

5.2: 0.75 h / 0 °C

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C

With sodium tetrahydroborate; trimethylsilyl iodide; N,N,N,N,-tetramethylethylenediamine; dimethylsulfide borane complex; ammonium acetate; N-ethyl-N,N-diisopropylamine; nickel (II) chloride hexahydrate; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1280210-82-3
(5S,6R)-6-(2,5-difluorophenyl)-5-nitropiperidin-2-one

: 1280211-13-3
tert-butyl [(2R,3S,5R)-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-1-(trifluoroacetyl)piperidin-3-yl]carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / nickel (II) chloride hexahydrate / methanol / 1 h / 0 °C

1.2: 15 h / 0 - 20 °C

2.1: N,N,N,N,-tetramethylethylenediamine; trimethylsilyl iodide / dichloromethane / 2 h / 0 °C

2.2: 3 h

2.3: 0.17 h

3.1: N,N,N,N,-tetramethylethylenediamine / dichloromethane; N,N-dimethyl-formamide / 64 h / 20 °C

4.1: dimethylsulfide borane complex / tetrahydrofuran / 1.25 h / 70 °C

4.2: 0.75 h / 0 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C

With sodium tetrahydroborate; trimethylsilyl iodide; N,N,N,N,-tetramethylethylenediamine; dimethylsulfide borane complex; N-ethyl-N,N-diisopropylamine; nickel (II) chloride hexahydrate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;