ethyl (2R,3S)-1-((4-chlorophenyl)sulfonyl)-3-(hexyloxy)pyrrolidine-2-carboxylate

Base Information

Chemical Name:ethyl (2R,3S)-1-((4-chlorophenyl)sulfonyl)-3-(hexyloxy)pyrrolidine-2-carboxylate
CAS No.:1408186-94-6
Molecular Formula:C₁₉H₂₈ClNO₅S
Molecular Weight:417.954
Hs Code.:

Synonyms:ethyl (2R,3S)-1-((4-chlorophenyl)sulfonyl)-3-(hexyloxy)pyrrolidine-2-carboxylate

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Chemical Property of ethyl (2R,3S)-1-((4-chlorophenyl)sulfonyl)-3-(hexyloxy)pyrrolidine-2-carboxylate

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Technology Process of ethyl (2R,3S)-1-((4-chlorophenyl)sulfonyl)-3-(hexyloxy)pyrrolidine-2-carboxylate

There total 5 articles about ethyl (2R,3S)-1-((4-chlorophenyl)sulfonyl)-3-(hexyloxy)pyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₃H₂₅NO₃

: 98-60-2
4-chlorobenzenesulfonyl chloride

: 1408186-94-6
ethyl (2R,3S)-1-((4-chlorophenyl)sulfonyl)-3-(hexyloxy)pyrrolidine-2-carboxylate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.ejmech.2012.08.028

Reference yield:

: 170123-25-8
3-oxo-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester

: 1408186-94-6
ethyl (2R,3S)-1-((4-chlorophenyl)sulfonyl)-3-(hexyloxy)pyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: calcium chloride; Sucrose / water / 48 h / 30 °C / Microbiological reaction

2: sodium hydride / N,N-dimethyl-formamide / 16 h / 0 - 20 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

4: triethylamine; dmap / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With dmap; sodium hydride; triethylamine; trifluoroacetic acid; calcium chloride; Sucrose; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.08.028

Reference yield:

: 3783-61-7
diethyl 2-azabutane-1,4-dicarboxylate

: 1408186-94-6
ethyl (2R,3S)-1-((4-chlorophenyl)sulfonyl)-3-(hexyloxy)pyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydroxide / chloroform; water / 73 h / 0 - 20 °C

2: potassium tert-butylate / toluene / 1.5 h / -10 - 0 °C / Inert atmosphere

3: calcium chloride; Sucrose / water / 48 h / 30 °C / Microbiological reaction

4: sodium hydride / N,N-dimethyl-formamide / 16 h / 0 - 20 °C / Inert atmosphere

5: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

6: triethylamine; dmap / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With dmap; potassium tert-butylate; sodium hydride; triethylamine; trifluoroacetic acid; calcium chloride; sodium hydroxide; Sucrose; In dichloromethane; chloroform; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.ejmech.2012.08.028