Dibenzyl-(5-bromo-pyrimidin-2-YL)-amine

Base Information

Chemical Name:Dibenzyl-(5-bromo-pyrimidin-2-YL)-amine
CAS No.:886366-28-5
Molecular Formula:C₁₈H₁₆BrN₃
Molecular Weight:354.249
Hs Code.:
DSSTox Substance ID:DTXSID901246309

Synonyms:886366-28-5;2-Pyrimidinamine, 5-bromo-N,N-bis(phenylmethyl)-;DIBENZYL-(5-BROMO-PYRIMIDIN-2-YL)-AMINE;N,N-dibenzyl-5-bromopyrimidin-2-amine;DTXSID901246309;AB15681;N,N-dibenzyl-2-amino-5-bromopyrimidine;5-Bromo-N,N-bis(phenylmethyl)-2-pyrimidinamine

Suppliers and Price of Dibenzyl-(5-bromo-pyrimidin-2-YL)-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of Dibenzyl-(5-bromo-pyrimidin-2-YL)-amine

Chemical Property:

XLogP3:4.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:353.05276
Heavy Atom Count:22
Complexity:286

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)CN(CC2=CC=CC=C2)C3=NC=C(C=N3)Br

Technology Process of Dibenzyl-(5-bromo-pyrimidin-2-YL)-amine

There total 1 articles about Dibenzyl-(5-bromo-pyrimidin-2-YL)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 7752-82-1
5-bromo-2-aminopyrimidine

: 100-39-0
benzyl bromide

: 886366-28-5
2?N,N?dibenzylamino?5?bromopyrimidine

Guidance literature:: 5-bromo-2-aminopyrimidine; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; Inert atmosphere;

benzyl bromide; In N,N-dimethyl-formamide; at 0 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jo9016919

Reference yield: 72.0%

: 886366-28-5
2?N,N?dibenzylamino?5?bromopyrimidine

: 100-51-6,185532-71-2
benzyl alcohol

: 2?N,N?dibenzylamino?5?benzyloxypyrimidine

Guidance literature:: 2?N,N?dibenzylamino?5?bromopyrimidine; With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate; In toluene; Schlenk technique; Inert atmosphere;

benzyl alcohol; In toluene; at 110 ℃; for 24h; Schlenk technique; Inert atmosphere;
DOI:10.1007/s13738-021-02387-6

Reference yield:

: 886366-28-5
2?N,N?dibenzylamino?5?bromopyrimidine

: 130222-84-3
5-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-D-ribono-1,4-lactone

: C₄₂H₄₇N₃O₅Si

Guidance literature:: 5-bromo-2-dibenzylaminopyrimidine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

5-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-D-ribono-1,4-lactone; In tetrahydrofuran; at -78 - 20 ℃; for 5h; Inert atmosphere;

With water; In tetrahydrofuran; at 20 ℃; stereoselective reaction;
DOI:10.1021/jo9016919