4-[(3-[4-(2-bromo-benzyloxycarbonyloxy)-phenyl]-2-{[4-(tert-butoxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-propionylamino)-methyl]-cyclohexanecarboxylic acid octyl ester

Base Information

Chemical Name:4-[(3-[4-(2-bromo-benzyloxycarbonyloxy)-phenyl]-2-{[4-(tert-butoxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-propionylamino)-methyl]-cyclohexanecarboxylic acid octyl ester
CAS No.:263272-43-1
Molecular Formula:C₄₆H₆₆BrN₃O₉
Molecular Weight:884.949
Hs Code.:

4-[(3-[4-(2-bromo-benzyloxycarbonyloxy)-phenyl]-2-{[4-(<i>tert</i>-butoxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-propionylamino)-methyl]-cyclohexanecarboxylic acid octyl ester

Synonyms:4-[(3-[4-(2-bromo-benzyloxycarbonyloxy)-phenyl]-2-{[4-(tert-butoxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-propionylamino)-methyl]-cyclohexanecarboxylic acid octyl ester

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Chemical Property of 4-[(3-[4-(2-bromo-benzyloxycarbonyloxy)-phenyl]-2-{[4-(tert-butoxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-propionylamino)-methyl]-cyclohexanecarboxylic acid octyl ester

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Technology Process of 4-[(3-[4-(2-bromo-benzyloxycarbonyloxy)-phenyl]-2-{[4-(tert-butoxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-propionylamino)-methyl]-cyclohexanecarboxylic acid octyl ester

There total 6 articles about 4-[(3-[4-(2-bromo-benzyloxycarbonyloxy)-phenyl]-2-{[4-(tert-butoxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-propionylamino)-methyl]-cyclohexanecarboxylic acid octyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 263272-46-4
C₁₈H₃₁NO₆

: 4-({(S)-2-Amino-3-[4-(2-bromo-benzyloxycarbonyloxy)-phenyl]-propionylamino}-methyl)-cyclohexanecarboxylic acid octyl ester; hydrochloride

: 263272-43-1
4-[(3-[4-(2-bromo-benzyloxycarbonyloxy)-phenyl]-2-{[4-(tert-butoxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-propionylamino)-methyl]-cyclohexanecarboxylic acid octyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 4 ℃;
DOI:10.1248/cpb.48.184

Reference yield:

: 27687-14-5
trans 4-(tert-butyloxycarbonylamino)methylcyclohexanecarboxylic acid

: 263272-43-1
4-[(3-[4-(2-bromo-benzyloxycarbonyloxy)-phenyl]-2-{[4-(tert-butoxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-propionylamino)-methyl]-cyclohexanecarboxylic acid octyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N

2: Et₃N / tetrahydrofuran; dimethylformamide / 4 °C

With triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Acylation / 2: Acylation;
DOI:10.1248/cpb.48.184

Reference yield:

: 780693-21-2
4-Aminomethyl-cyclohexanecarboxylic acid octyl ester

: 263272-43-1
4-[(3-[4-(2-bromo-benzyloxycarbonyloxy)-phenyl]-2-{[4-(tert-butoxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-propionylamino)-methyl]-cyclohexanecarboxylic acid octyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 4 °C

2: HCl / dioxane

3: Et₃N / tetrahydrofuran; dimethylformamide / 4 °C

With hydrogenchloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; 1: Acylation / 2: Acidolysis / 3: Acylation;
DOI:10.1248/cpb.48.184