2-(4-(2-aminopyridin-4-yloxy)-3-fluorophenylamino)-5-methyl-N-phenylnicotinamide

Base Information

Chemical Name:2-(4-(2-aminopyridin-4-yloxy)-3-fluorophenylamino)-5-methyl-N-phenylnicotinamide
CAS No.:1036405-43-2
Molecular Formula:C₂₄H₂₀FN₅O₂
Molecular Weight:429.454
Hs Code.:

Synonyms:2-(4-(2-aminopyridin-4-yloxy)-3-fluorophenylamino)-5-methyl-N-phenylnicotinamide

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Chemical Property of 2-(4-(2-aminopyridin-4-yloxy)-3-fluorophenylamino)-5-methyl-N-phenylnicotinamide

Chemical Property:

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Technology Process of 2-(4-(2-aminopyridin-4-yloxy)-3-fluorophenylamino)-5-methyl-N-phenylnicotinamide

There total 1 articles about 2-(4-(2-aminopyridin-4-yloxy)-3-fluorophenylamino)-5-methyl-N-phenylnicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 19798-80-2
2-Amino-4-chloropyridine

: C₁₈H₁₄FN₃O₂

: 1036405-41-0
2-(3-fluoro-4-hydroxyphenylamino)-5-methyl-N-phenylnicotinamide

: C₂₃H₁₈FN₅O₂

: 1036405-43-2
2-(4-(2-aminopyridin-4-yloxy)-3-fluorophenylamino)-5-methyl-N-phenylnicotinamide

Guidance literature:: 2-Amino-4-chloropyridine; C₁₈H₁₄FN₃O₂; 2-(3-fluoro-4-hydroxyphenylamino)-5-methyl-N-phenylnicotinamide; With triethylamine; In 1-methyl-pyrrolidin-2-one; at 185 - 190 ℃; for 22h;

2-Amino-4-chloropyridine; With dmap; triethylamine; In 1-methyl-pyrrolidin-2-one; at 190 ℃; for 24h;

Reference yield:

: 110-91-8,99108-56-2
morpholine

: 1036405-43-2
2-(4-(2-aminopyridin-4-yloxy)-3-fluorophenylamino)-5-methyl-N-phenylnicotinamide

: 1885-14-9
phenyl chloroformate

: 1036405-03-4
N-(4-(2-fluoro-4-(5-methyl-3-(phenylcarbamoyl)pyridin-2-ylamino)phenoxy)pyridin-2-yl)morpholine-4-carboxamide

Guidance literature:: 2-(4-(2-aminopyridin-4-yloxy)-3-fluorophenylamino)-5-methyl-N-phenylnicotinamide; phenyl chloroformate; With triethylamine; In tetrahydrofuran; at 20 ℃; for 0.5h;

morpholine; In tetrahydrofuran; at 20 - 70 ℃;