1-(2-methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanone

Base Information

Chemical Name:1-(2-methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanone
CAS No.:1350374-44-5
Molecular Formula:C₁₅H₂₁BO₄
Molecular Weight:276.14
Hs Code.:

Synonyms:1-(2-methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanone

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Chemical Property of 1-(2-methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanone

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Technology Process of 1-(2-methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanone

There total 1 articles about 1-(2-methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 579-74-8
2-Methoxyacetophenone

: 73183-34-3
bis(pinacol)diborane

: 1350374-44-5
1-(2-methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanone

Guidance literature:: bis(pinacol)diborane; With 5-methyl-2-(thiophen-3-yl)pyridine; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; In tetrahydrofuran; at 20 ℃; for 0.0333333h; Inert atmosphere; Glovebox;

2-Methoxyacetophenone; In tetrahydrofuran; at 80 ℃; for 24h; regioselective reaction; Inert atmosphere; Sealed tube;
DOI:10.1021/jacs.0c13415

Reference yield: 58.0%

: 1350374-44-5
1-(2-methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanone

: 93493-95-9
2-{[(trifluoromethyl)sulfonyl]oxy}cyclohex-1-enecarboxylic acid methyl ester

: C₁₇H₂₀O₄

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In 1,2-dimethoxyethane; water; at 85 ℃; for 2h; Inert atmosphere;
DOI:10.1002/anie.201505993

Reference yield:

: 1350374-44-5
1-(2-methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanone

: 93493-95-9
2-{[(trifluoromethyl)sulfonyl]oxy}cyclohex-1-enecarboxylic acid methyl ester

: C₂₄H₂₈N₂O₅S

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / 1,2-dimethoxyethane / 2 h / 85 °C / Inert atmosphere

2: toluene / 12 h / 60 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In 1,2-dimethoxyethane; toluene; 1: |Suzuki-Miyaura Coupling;
DOI:10.1021/acs.orglett.7b01694