tri-tert-butyl 2,2',2''-(10-(2-((2-(((benzyloxy)carbonyl)amino)ethyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Base Information

• Chemical Name: tri-tert-butyl 2,2',2''-(10-(2-((2-(((benzyloxy)carbonyl)amino)ethyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate
• CAS No.: 1027359-40-5
• Molecular Formula: C₃₈H₆₄N₆O₉
• Molecular Weight: 748.961

Synonyms:tri-tert-butyl 2,2',2''-(10-(2-((2-(((benzyloxy)carbonyl)amino)ethyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Chemical Property of tri-tert-butyl 2,2',2''-(10-(2-((2-(((benzyloxy)carbonyl)amino)ethyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

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Technology Process of tri-tert-butyl 2,2',2''-(10-(2-((2-(((benzyloxy)carbonyl)amino)ethyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

There total 5 articles about tri-tert-butyl 2,2',2''-(10-(2-((2-(((benzyloxy)carbonyl)amino)ethyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-(2-benzyloxycarbonylaminoethyl)bromoacetamide (1027359-36-9) + 1,4,7-tris-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododecane (122555-91-3) → tri-tert-butyl 2,2',2''-(10-(2-((2-(((benzyloxy)carbonyl)amino)ethyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate (1027359-40-5)

Guidance literature:

With potassium carbonate; In acetonitrile; at 0 - 20 ℃; for 5h;

DOI:10.1039/b715844k

Reference yield: 80.0%

N-(2-benzyloxycarbonylaminoethyl)bromoacetamide (1027359-36-9) + tris(tert-butyl) 2,2',2''-(1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate hydrobromide → tri-tert-butyl 2,2',2''-(10-(2-((2-(((benzyloxy)carbonyl)amino)ethyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate (1027359-40-5)

Guidance literature:

With Amberlite IRA 410; In acetonitrile; at 20 ℃; for 4h;

DOI:10.1039/b715844k

Reference yield:

1-N-chloroacetyl-2-N'-Cbz(ethylenediamine) (223742-32-3) + 1,4,7-tris-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododecane (122555-91-3) → tri-tert-butyl 2,2',2''-(10-(2-((2-(((benzyloxy)carbonyl)amino)ethyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate (1027359-40-5)

Guidance literature:

With potassium carbonate; In acetonitrile; at 60 ℃; for 18h;

DOI:10.1016/j.tetlet.2009.12.086

upstream raw materials:

N-(2-benzyloxycarbonylaminoethyl)bromoacetamide

1,4,7-tris-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododecane

1-N-chloroacetyl-2-N'-Cbz(ethylenediamine)

1,4,7,10-tetraazacyclododecan

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