223742-32-3Relevant academic research and scientific papers
A bifunctional chelator featuring the DOTAM-Gly-l-Phe-OH structural subunit: en route toward homo- and heterobimetallic lanthanide(III) complexes as PARACEST MRI contrast agents
Suchy, Mojmír,Li, Alex X.,Bartha, Robert,Hudson, Robert H.E.
supporting information; experimental part, p. 1087 - 1090 (2010/04/05)
A new synthesis of a bifunctional chelator possessing DOTAM-Gly-l-Phe-OH and DO3A chelating cages interconnected by an oligoamide chain has been achieved via HBTU-mediated coupling from easily accessible building blocks. Both homo- and heterobimetallic lanthanide(III) complexes derived from this bifunctional chelator have been prepared in moderate yields. The CEST spectrum acquired for homobimetallic Eu3+ complex showed this molecule to be a promising PARACEST MRI contrast agent whereas the Eu3+/Tm3+ heterobimetallic complex lacked a useful CEST signal.
