Technology Process of 5-benzyloxy-6-[5-(4-fluorobenzyl)[1,3,4]oxadiazol-2-yl]-3-methyl-3H-pyrimidine-4-thione
There total 13 articles about 5-benzyloxy-6-[5-(4-fluorobenzyl)[1,3,4]oxadiazol-2-yl]-3-methyl-3H-pyrimidine-4-thione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: thionyl chloride / 1 h / 80 °C
2: hydrazine hydrate / dichloromethane / 1.5 h / 0 - 20 °C
3: triethylamine / dichloromethane / 0 - 20 °C
4: triphenylphosphine; tetrachloromethane / acetonitrile / 20 °C
5: Lawessons reagent / toluene / 14 h / 80 - 85 °C
With
Lawessons reagent; tetrachloromethane; thionyl chloride; hydrazine hydrate; triethylamine; triphenylphosphine;
In
dichloromethane; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: hydrazine hydrate / dichloromethane / 1.5 h / 0 - 20 °C
2: triethylamine / dichloromethane / 0 - 20 °C
3: triphenylphosphine; tetrachloromethane / acetonitrile / 20 °C
4: Lawessons reagent / toluene / 14 h / 80 - 85 °C
With
Lawessons reagent; tetrachloromethane; hydrazine hydrate; triethylamine; triphenylphosphine;
In
dichloromethane; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 20 h / 0 - 20 °C
2: lithium diisopropyl amide / tetrahydrofuran / 2 h / -78 - 20 °C
3: sodium methylate / methanol / 17.25 h / 0 - 20 °C
4: sodium hydride / N,N-dimethyl-formamide / 2.25 h / 0 - 20 °C
5: sodium hydroxide; water / ethanol / 20 h / 25 °C
6: thionyl chloride / 1 h / Reflux
7: triethylamine / dichloromethane / 0 - 20 °C
8: triphenylphosphine; tetrachloromethane / acetonitrile / 20 °C
9: Lawessons reagent / toluene / 14 h / 80 - 85 °C
With
Lawessons reagent; tetrachloromethane; thionyl chloride; water; sodium methylate; sodium hydride; triethylamine; triphenylphosphine; sodium hydroxide; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
