4-chloro-N-((6,7-dimethoxyquinolin-4-yl)methyl)-2-vinylbenzamide

Base Information

Chemical Name:4-chloro-N-((6,7-dimethoxyquinolin-4-yl)methyl)-2-vinylbenzamide
CAS No.:1035700-02-7
Molecular Formula:C₂₁H₁₉ClN₂O₃
Molecular Weight:382.846
Hs Code.:

Synonyms:4-chloro-N-((6,7-dimethoxyquinolin-4-yl)methyl)-2-vinylbenzamide

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Chemical Property of 4-chloro-N-((6,7-dimethoxyquinolin-4-yl)methyl)-2-vinylbenzamide

Chemical Property:

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Technology Process of 4-chloro-N-((6,7-dimethoxyquinolin-4-yl)methyl)-2-vinylbenzamide

There total 4 articles about 4-chloro-N-((6,7-dimethoxyquinolin-4-yl)methyl)-2-vinylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1035699-99-0
4-chloro-2-vinylbenzoic acid

: 1035700-00-5
(6,7-dimethoxyquinolin-4-yl)methanaminium chloride

: 1035700-02-7
4-chloro-N-((6,7-dimethoxyquinolin-4-yl)methyl)-2-vinylbenzamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 89-77-0
2-Amino-4-chlorobenzoic acid

: 1035700-02-7
4-chloro-N-((6,7-dimethoxyquinolin-4-yl)methyl)-2-vinylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: tert.-butylnitrite; boron trifluoride diethyl etherate / tetrahydrofuran / 0.67 h / -15 - 5 °C

2: trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II) / methanol / 0.5 h / 20 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C

With tert.-butylnitrite; boron trifluoride diethyl etherate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 35654-56-9
6,7-dimethoxy-4-chloroquinoline

: 1035700-02-7
4-chloro-N-((6,7-dimethoxyquinolin-4-yl)methyl)-2-vinylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; zinc / N,N-dimethyl acetamide / 0.17 h / 150 °C / Microwave

2: hydrogenchloride; hydrogen / palladium on activated charcoal / ethanol

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C

With hydrogenchloride; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium on activated charcoal; zinc; In ethanol; dichloromethane; N,N-dimethyl acetamide;