[(1S,2R)-3-((3S,4aS,8aS)-3-tert-Butylcarbamoyl-octahydro-isoquinolin-2-yl)-2-hydroxy-1-phenylsulfanylmethyl-propyl]-carbamic acid benzyl ester

Base Information

Chemical Name:[(1S,2R)-3-((3S,4aS,8aS)-3-tert-Butylcarbamoyl-octahydro-isoquinolin-2-yl)-2-hydroxy-1-phenylsulfanylmethyl-propyl]-carbamic acid benzyl ester
CAS No.:159991-24-9
Molecular Formula:C₃₂H₄₅N₃O₄S
Molecular Weight:567.793
Hs Code.:

[(1S,2R)-3-((3S,4aS,8aS)-3-tert-Butylcarbamoyl-octahydro-isoquinolin-2-yl)-2-hydroxy-1-phenylsulfanylmethyl-propyl]-carbamic acid benzyl ester

Synonyms:[(1S,2R)-3-((3S,4aS,8aS)-3-tert-Butylcarbamoyl-octahydro-isoquinolin-2-yl)-2-hydroxy-1-phenylsulfanylmethyl-propyl]-carbamic acid benzyl ester

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Chemical Property of [(1S,2R)-3-((3S,4aS,8aS)-3-tert-Butylcarbamoyl-octahydro-isoquinolin-2-yl)-2-hydroxy-1-phenylsulfanylmethyl-propyl]-carbamic acid benzyl ester

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Technology Process of [(1S,2R)-3-((3S,4aS,8aS)-3-tert-Butylcarbamoyl-octahydro-isoquinolin-2-yl)-2-hydroxy-1-phenylsulfanylmethyl-propyl]-carbamic acid benzyl ester

There total 8 articles about [(1S,2R)-3-((3S,4aS,8aS)-3-tert-Butylcarbamoyl-octahydro-isoquinolin-2-yl)-2-hydroxy-1-phenylsulfanylmethyl-propyl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 65-85-0,8013-63-6
benzoic acid

: 159991-24-9
[(1S,2R)-3-((3S,4aS,8aS)-3-tert-Butylcarbamoyl-octahydro-isoquinolin-2-yl)-2-hydroxy-1-phenylsulfanylmethyl-propyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: H₂ / Pd/C / propan-2-ol / 9 h / 60 °C

2: K₂CO₃ / toluene; H₂O / 3 h / 20 °C

3: Et₃N / toluene / 1.5 h / 10 °C

4: NaOH; Bu₄NBr / toluene; H₂O / 2.5 h / 55 °C

5: aq. HCl / methanol / 3.5 h / Heating

6: 67 percent / pyridine / 4.25 h / 0 - 20 °C

7: 92 percent / KOH / propan-2-ol; H₂O / 1 h / 20 °C

8: K₂CO₃ / propan-2-ol / 4 h / 80 °C

With pyridine; hydrogenchloride; potassium hydroxide; sodium hydroxide; tetrabutylammomium bromide; hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; In methanol; water; isopropyl alcohol; toluene; 1: Hydrogenolysis / 2: Condensation / 3: Condensation / 4: Substitution / 5: Hydrolysis / 6: Tosylation / 7: Cyclization / 8: Addition;
DOI:10.1021/jo991793e

Reference yield:

: 128019-40-9,149510-73-6,136465-81-1,168899-60-3
(3S,4aS,8aS)-N-tert-butyl-decahydroisoquinoline-3-carboxamide

: (2S,3S)-3-benzyloxycarbonylamino-4-(phenylthio)1-buteneoxide

: 159991-24-9
[(1S,2R)-3-((3S,4aS,8aS)-3-tert-Butylcarbamoyl-octahydro-isoquinolin-2-yl)-2-hydroxy-1-phenylsulfanylmethyl-propyl]-carbamic acid benzyl ester

Guidance literature:: With potassium carbonate; In isopropyl alcohol; at 80 ℃; for 4h;
DOI:10.1021/jo991793e

Reference yield:

: 1010701-95-7
(2R)-2-benzyloxycarbonylamino-2-[(4S)-2,2-dimethyl-1,3-dioxolane-4-yl]ethanol

: 159991-24-9
[(1S,2R)-3-((3S,4aS,8aS)-3-tert-Butylcarbamoyl-octahydro-isoquinolin-2-yl)-2-hydroxy-1-phenylsulfanylmethyl-propyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N / toluene / 1.5 h / 10 °C

2: NaOH; Bu₄NBr / toluene; H₂O / 2.5 h / 55 °C

3: aq. HCl / methanol / 3.5 h / Heating

4: 67 percent / pyridine / 4.25 h / 0 - 20 °C

5: 92 percent / KOH / propan-2-ol; H₂O / 1 h / 20 °C

6: K₂CO₃ / propan-2-ol / 4 h / 80 °C

With pyridine; hydrogenchloride; potassium hydroxide; sodium hydroxide; tetrabutylammomium bromide; potassium carbonate; triethylamine; In methanol; water; isopropyl alcohol; toluene; 1: Condensation / 2: Substitution / 3: Hydrolysis / 4: Tosylation / 5: Cyclization / 6: Addition;
DOI:10.1021/jo991793e