(R)-2-(benzyloxycarbonylamino)-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethyl methanesulfonate

Base Information

Chemical Name:(R)-2-(benzyloxycarbonylamino)-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethyl methanesulfonate
CAS No.:1010701-97-9
Molecular Formula:C₁₆H₂₃NO₇S
Molecular Weight:373.427
Hs Code.:

Synonyms:(R)-2-(benzyloxycarbonylamino)-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethyl methanesulfonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-(benzyloxycarbonylamino)-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethyl methanesulfonate

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Technology Process of (R)-2-(benzyloxycarbonylamino)-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethyl methanesulfonate

There total 5 articles about (R)-2-(benzyloxycarbonylamino)-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 124-63-0
methanesulfonyl chloride

: 1010701-95-7
(2R)-2-benzyloxycarbonylamino-2-[(4S)-2,2-dimethyl-1,3-dioxolane-4-yl]ethanol

: 1010701-97-9
(R)-2-(benzyloxycarbonylamino)-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethyl methanesulfonate

Guidance literature:: With triethylamine; In toluene; at 0 - 20 ℃; for 1.5h;

Reference yield:

: 65-85-0,8013-63-6
benzoic acid

: 1010701-97-9
(R)-2-(benzyloxycarbonylamino)-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethyl methanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C / propan-2-ol / 9 h / 60 °C

2: K₂CO₃ / toluene; H₂O / 3 h / 20 °C

3: Et₃N / toluene / 1.5 h / 10 °C

With hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; In water; isopropyl alcohol; toluene; 1: Hydrogenolysis / 2: Condensation / 3: Condensation;
DOI:10.1021/jo991793e

Reference yield:

: (5R,6S)-2,2-dimethyl-6-(1-phenylmethylamino)-1,3-dioxepan-5-ol

: 1010701-97-9
(R)-2-(benzyloxycarbonylamino)-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethyl methanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: MsOH; Me₂C(OMe)2 / acetone / 4 h

2: H₂ / Pd/C / propan-2-ol / 9 h / 60 °C

3: K₂CO₃ / toluene; H₂O / 3 h / 20 °C

4: Et₃N / toluene / 1.5 h / 10 °C

With methanesulfonic acid; hydrogen; potassium carbonate; triethylamine; 2,2-dimethoxy-propane; palladium on activated charcoal; In water; isopropyl alcohol; acetone; toluene; 1: Isomerization / 2: Hydrogenolysis / 3: Condensation / 4: Condensation;
DOI:10.1021/jo991793e