5-[2-(4-isopropylsulfonylphenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-3-phenyl-isoxazole

Base Information

Chemical Name:5-[2-(4-isopropylsulfonylphenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-3-phenyl-isoxazole
CAS No.:1353571-18-2
Molecular Formula:C₂₄H₂₀N₄O₃S
Molecular Weight:444.514
Hs Code.:

Synonyms:5-[2-(4-isopropylsulfonylphenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-3-phenyl-isoxazole

Suppliers and Price of 5-[2-(4-isopropylsulfonylphenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-3-phenyl-isoxazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-[2-(4-isopropylsulfonylphenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-3-phenyl-isoxazole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-[2-(4-isopropylsulfonylphenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-3-phenyl-isoxazole

There total 14 articles about 5-[2-(4-isopropylsulfonylphenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-3-phenyl-isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1353571-95-5
5-[2-(4-isopropylsulfonylphenyl)-5-(p-tolylsulfonyl)pyrrolo[2,3-b]pyrazin-7-yl]-3-phenyl-isoxazole

: 1353571-18-2
5-[2-(4-isopropylsulfonylphenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-3-phenyl-isoxazole

Guidance literature:: With sodium carbonate; In tetrahydrofuran; at 20 ℃; for 64h;

Reference yield:

: 850567-98-5
4-(isopropylsulfonyl)phenylboronic acid

: 1353571-18-2
5-[2-(4-isopropylsulfonylphenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-3-phenyl-isoxazole

Guidance literature:: Multi-step reaction with 14 steps

1.1: potassium phosphate / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / acetonitrile; water / 1 h / 60 °C

2.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 2 h / 20 °C

3.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 2.17 h / 0 - 20 °C

3.2: 0 - 20 °C

4.1: dmap; triethylamine / dichloromethane / 16 h / 20 °C

5.1: water; sodium carbonate / methanol / 1 h / 20 °C

6.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

6.2: 0.5 h

7.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one

8.1: pyridine; Iodine monochloride / dichloromethane / 21.5 h / 0 - 20 °C

9.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C

9.2: 16 h / 20 °C

10.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 64 h / 0 - 20 °C

11.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C

12.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C

12.2: 16 h / 20 °C

13.1: triethylamine / tetrahydrofuran / 3.75 h / 20 - 65 °C

14.1: sodium carbonate / tetrahydrofuran / 64 h / 20 °C

With pyridine; dmap; potassium phosphate; N-Bromosuccinimide; potassium tert-butylate; tetrabutyl ammonium fluoride; water; Iodine monochloride; sodium hydride; sodium carbonate; triethylamine; trifluoroacetic acid; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 1349151-81-0
5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-amine

: 1353571-18-2
5-[2-(4-isopropylsulfonylphenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-3-phenyl-isoxazole

Guidance literature:: Multi-step reaction with 13 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 2 h / 20 °C

2.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 2.17 h / 0 - 20 °C

2.2: 0 - 20 °C

3.1: dmap; triethylamine / dichloromethane / 16 h / 20 °C

4.1: water; sodium carbonate / methanol / 1 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

5.2: 0.5 h

6.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one

7.1: pyridine; Iodine monochloride / dichloromethane / 21.5 h / 0 - 20 °C

8.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C

8.2: 16 h / 20 °C

9.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 64 h / 0 - 20 °C

10.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C

11.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C

11.2: 16 h / 20 °C

12.1: triethylamine / tetrahydrofuran / 3.75 h / 20 - 65 °C

13.1: sodium carbonate / tetrahydrofuran / 64 h / 20 °C

With pyridine; dmap; N-Bromosuccinimide; potassium tert-butylate; tetrabutyl ammonium fluoride; water; Iodine monochloride; sodium hydride; sodium carbonate; triethylamine; trifluoroacetic acid; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;