C₂₇H₂₇N₃O₆S

Base Information

• Chemical Name: C₂₇H₂₇N₃O₆S
• CAS No.: 1374110-25-4
• Molecular Formula: C₂₇H₂₇N₃O₆S
• Molecular Weight: 521.594
• Mol file: 1374110-25-4.mol

Synonyms:C₂₇H₂₇N₃O₆S

Chemical Property of C₂₇H₂₇N₃O₆S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₇H₂₇N₃O₆S

There total 6 articles about C₂₇H₂₇N₃O₆S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

C33H41N3O6SSi (1374110-24-3) → C27H27N3O6S (1374110-25-4)

Guidance literature:

With trifluoroacetic acid; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

quinoline-2,6-diol (19315-93-6) → C27H27N3O6S (1374110-25-4)

Guidance literature:

Multi-step reaction with 6 steps

1: thionyl chloride; N,N-dimethyl-formamide / 16 h / 20 °C / Cooling with ice

2: pyridinium p-toluenesulfonate / tetrahydrofuran / 2.5 h / 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,2-dimethoxyethane / 16 h / 80 °C / Inert atmosphere

4: trifluoroacetic acid / chloroform / 0.5 h / 20 °C / Cooling with ice

5: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 16.33 h / 20 °C / Cooling with ice

6: trifluoroacetic acid / tetrahydrofuran / 16 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; di-isopropyl azodicarboxylate; pyridinium p-toluenesulfonate; potassium carbonate; N,N-dimethyl-formamide; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; chloroform; water;

Reference yield:

6-hydroxy-2-chloroquinoline (577967-89-6) → C27H27N3O6S (1374110-25-4)

Guidance literature:

Multi-step reaction with 5 steps

1: pyridinium p-toluenesulfonate / tetrahydrofuran / 2.5 h / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,2-dimethoxyethane / 16 h / 80 °C / Inert atmosphere

3: trifluoroacetic acid / chloroform / 0.5 h / 20 °C / Cooling with ice

4: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 16.33 h / 20 °C / Cooling with ice

5: trifluoroacetic acid / tetrahydrofuran / 16 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; di-isopropyl azodicarboxylate; pyridinium p-toluenesulfonate; potassium carbonate; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; chloroform; water;

upstream raw materials:

C₃₃H₄₁N₃O₆SSi

quinoline-2,6-diol

6-hydroxy-2-chloroquinoline

C₁₃H₁₄ClNO₂

Downstream raw materials:

6-[[2-(tetrahydro-2H-pyran-2-yloxy)-tosyloxy]propoxy]-2-(4-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)quinoline