1H-tetrazole-5-carboxylic acid 3-acetyl-2-hydroxy-5-methyl-anilide

Base Information

• Chemical Name: 1H-tetrazole-5-carboxylic acid 3-acetyl-2-hydroxy-5-methyl-anilide
• CAS No.: 70977-39-8
• Molecular Formula: C₁₁H₁₁N₅O₃
• Molecular Weight: 261.24
• Mol file: 70977-39-8.mol

Synonyms:1H-tetrazole-5-carboxylic acid 3-acetyl-2-hydroxy-5-methyl-anilide

Chemical Property of 1H-tetrazole-5-carboxylic acid 3-acetyl-2-hydroxy-5-methyl-anilide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1H-tetrazole-5-carboxylic acid 3-acetyl-2-hydroxy-5-methyl-anilide

There total 6 articles about 1H-tetrazole-5-carboxylic acid 3-acetyl-2-hydroxy-5-methyl-anilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-(4-methoxy-benzyl)-1H-tetrazole-5-carboxylic acid 3-acetyl-2-hydroxy-5-methyl-anilide (70977-89-8) → 1H-tetrazole-5-carboxylic acid 3-acetyl-2-hydroxy-5-methyl-anilide (70977-39-8)

Guidance literature:

With trifluoroacetic acid; for 0.5h; Heating;

DOI:10.1021/jm00154a019

Reference yield: 26.0%

3-acetyl-2-hydroxy-5-methylcyanoformanilide (100245-21-4) → 1H-tetrazole-5-carboxylic acid 3-acetyl-2-hydroxy-5-methyl-anilide (70977-39-8)

Guidance literature:

With aluminium trichloride; sodium azide; In tetrahydrofuran; for 24h; Heating;

DOI:10.1021/jm00154a019

Reference yield: 17.0%

1-benzyl-1H-tetrazole-5-carboxylic acid 3-acetyl-2-hydroxy-5-methyl-anilide (70977-74-1) → 1H-tetrazole-5-carboxylic acid 3-acetyl-2-hydroxy-5-methyl-anilide (70977-39-8)

Guidance literature:

With hydrogen; acetic acid; palladium on activated charcoal; at 20 ℃; under 3102.9 Torr;

DOI:10.1021/jm00154a019

upstream raw materials:

1-benzyl-1H-tetrazole-5-carboxylic acid 3-acetyl-2-hydroxy-5-methyl-anilide

1-(4-methoxy-benzyl)-1H-tetrazole-5-carboxylic acid 3-acetyl-2-hydroxy-5-methyl-anilide

3-acetyl-2-hydroxy-5-methylcyanoformanilide

2-hydroxy-5-methyl-3-nitroacetophenone

Downstream raw materials:

N-(3-acetyl-2-hydroxy-5-methylphenyl)-1H-tetrazole-5-carboxamide methoxime

N-(3-acetyl-2-hydroxy-5-methylphenyl)-1H-tetrazole-5-carboxamide oxime

5'-ethyl-2'-hydroxy-3'-(1-hydroxyimino)ethyltetrazole-5-carboxanilide

2'-hydroxy-3'-(1-hydroxyimino)ethyl-5'-methyltetrazole-5-carboxanilide