N-[6-chloro-4,4-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-8-carbonyl]-methanesulfonamide

Base Information

Chemical Name:N-[6-chloro-4,4-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-8-carbonyl]-methanesulfonamide
CAS No.:1391610-16-4
Molecular Formula:C₂₃H₂₈ClN₃O₄S
Molecular Weight:478.012
Hs Code.:

Synonyms:N-[6-chloro-4,4-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-8-carbonyl]-methanesulfonamide

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Chemical Property of N-[6-chloro-4,4-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-8-carbonyl]-methanesulfonamide

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Technology Process of N-[6-chloro-4,4-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-8-carbonyl]-methanesulfonamide

There total 4 articles about N-[6-chloro-4,4-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-8-carbonyl]-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 3144-09-0
methanesulfonamide

: 1391610-17-5
6-chloro-4,4-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-8-carboxylic acid

: 1391610-16-4
N-[6-chloro-4,4-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-8-carbonyl]-methanesulfonamide

Guidance literature:: methanesulfonamide; With sodium hydride; In N,N-dimethyl-formamide; at 25 ℃; for 1h;

6-chloro-4,4-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-8-carboxylic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 25 - 70 ℃; for 2h;

Reference yield:

: 3132-99-8
m-bromobenzoic aldehyde

: 1391610-16-4
N-[6-chloro-4,4-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-8-carbonyl]-methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ytterbium(III) trifluoromethanesulfonate hydrate / acetonitrile / 12 h / 90 °C / sealed reaction bottle

2.1: potassium carbonate; copper(l) iodide; N,N-dimethylglycine hydrochoride / dimethyl sulfoxide / 16 h / 120 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 25 °C

3.2: 2 h / 25 - 70 °C

With copper(l) iodide; ytterbium(III) trifluoromethanesulfonate hydrate; N,N-dimethylglycine hydrochoride; sodium hydride; potassium carbonate; In dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1373546-27-0
2-(3-bromo-phenyl)-6-chloro-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline-8-carboxylic acid methyl ester

: 1391610-16-4
N-[6-chloro-4,4-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-8-carbonyl]-methanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate; copper(l) iodide; N,N-dimethylglycine hydrochoride / dimethyl sulfoxide / 16 h / 120 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 25 °C

2.2: 2 h / 25 - 70 °C

With copper(l) iodide; N,N-dimethylglycine hydrochoride; sodium hydride; potassium carbonate; In dimethyl sulfoxide; N,N-dimethyl-formamide;