5-(1-hydroxy-6,6-dimethyl-hepta-2,4-diynyl)-4-[4-(2-(methoxymethyl)-phenyl)-buta-1,3-diynyl]-thiophene-2-carboxylic acid triisopropylsilyl ester

Base Information

• Chemical Name: 5-(1-hydroxy-6,6-dimethyl-hepta-2,4-diynyl)-4-[4-(2-(methoxymethyl)-phenyl)-buta-1,3-diynyl]-thiophene-2-carboxylic acid triisopropylsilyl ester
• CAS No.: 1041857-85-5
• Molecular Formula: C₃₅H₄₂O₄SSi
• Molecular Weight: 586.868

Synonyms:5-(1-hydroxy-6,6-dimethyl-hepta-2,4-diynyl)-4-[4-(2-(methoxymethyl)-phenyl)-buta-1,3-diynyl]-thiophene-2-carboxylic acid triisopropylsilyl ester

Chemical Property of 5-(1-hydroxy-6,6-dimethyl-hepta-2,4-diynyl)-4-[4-(2-(methoxymethyl)-phenyl)-buta-1,3-diynyl]-thiophene-2-carboxylic acid triisopropylsilyl ester

Chemical Property:

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Technology Process of 5-(1-hydroxy-6,6-dimethyl-hepta-2,4-diynyl)-4-[4-(2-(methoxymethyl)-phenyl)-buta-1,3-diynyl]-thiophene-2-carboxylic acid triisopropylsilyl ester

There total 1 articles about 5-(1-hydroxy-6,6-dimethyl-hepta-2,4-diynyl)-4-[4-(2-(methoxymethyl)-phenyl)-buta-1,3-diynyl]-thiophene-2-carboxylic acid triisopropylsilyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

5-formyl-4-[4-(2-(methoxymethyl)-phenyl)-buta-1,3-diynyl]-thiophene-2-carboxylic acid triisopropylsilyl ester (1041857-84-4) + 1-trimethylsilyl-4-t-butyl-1,3-butadiyne (84751-19-9) → 5-(1-hydroxy-6,6-dimethyl-hepta-2,4-diynyl)-4-[4-(2-(methoxymethyl)-phenyl)-buta-1,3-diynyl]-thiophene-2-carboxylic acid triisopropylsilyl ester (1041857-85-5)

Guidance literature:

1-trimethylsilyl-4-t-butyl-1,3-butadiyne; With methyllithium; In diethyl ether; for 3h; Heating;

5-formyl-4-[4-(2-(methoxymethyl)-phenyl)-buta-1,3-diynyl]-thiophene-2-carboxylic acid triisopropylsilyl ester; In diethyl ether; at -72 - -48 ℃; for 2h; Further stages.;

DOI:10.1016/j.bmc.2008.04.009

Reference yield: 98.0%

5-(1-hydroxy-6,6-dimethyl-hepta-2,4-diynyl)-4-[4-(2-(methoxymethyl)-phenyl)-buta-1,3-diynyl]-thiophene-2-carboxylic acid triisopropylsilyl ester (1041857-85-5) → C35H40O4SSi

Guidance literature:

With manganese(IV) oxide; sodium sulfate; In dichloromethane; at 0 - 7 ℃; for 27h;

DOI:10.1016/j.bmc.2008.04.009

Reference yield: 85.0%

5-(1-hydroxy-6,6-dimethyl-hepta-2,4-diynyl)-4-[4-(2-(methoxymethyl)-phenyl)-buta-1,3-diynyl]-thiophene-2-carboxylic acid triisopropylsilyl ester (1041857-85-5) → 5-(1-hydroxy-6,6-dimethyl-hepta-2,4-diynyl)-4-[4-(2-(methoxymethyl)-phenyl)-buta-1,3-diynyl]-thiophene-2-carboxylic acid (1041857-86-6)

Guidance literature:

With methanol; potassium carbonate; at 20 ℃; for 5h;

DOI:10.1016/j.bmc.2008.04.009

upstream raw materials:

5-formyl-4-[4-(2-(methoxymethyl)-phenyl)-buta-1,3-diynyl]-thiophene-2-carboxylic acid triisopropylsilyl ester

1-trimethylsilyl-4-t-butyl-1,3-butadiyne

Downstream raw materials:

5-(1-hydroxy-6,6-dimethyl-hepta-2,4-diynyl)-4-[4-(2-(methoxymethyl)-phenyl)-buta-1,3-diynyl]-thiophene-2-carboxylic acid

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