N-(4-Methoxyphenyl)-N-(1,1,1-trifluor-2-propyl)-2-fluor-4-methoxybenzamid

Base Information

• Chemical Name: N-(4-Methoxyphenyl)-N-(1,1,1-trifluor-2-propyl)-2-fluor-4-methoxybenzamid
• CAS No.: 127817-88-3
• Molecular Formula: C₁₈H₁₇F₄NO₃
• Molecular Weight: 371.331

Synonyms:N-(4-Methoxyphenyl)-N-(1,1,1-trifluor-2-propyl)-2-fluor-4-methoxybenzamid

Chemical Property of N-(4-Methoxyphenyl)-N-(1,1,1-trifluor-2-propyl)-2-fluor-4-methoxybenzamid

Chemical Property:

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Technology Process of N-(4-Methoxyphenyl)-N-(1,1,1-trifluor-2-propyl)-2-fluor-4-methoxybenzamid

There total 2 articles about N-(4-Methoxyphenyl)-N-(1,1,1-trifluor-2-propyl)-2-fluor-4-methoxybenzamid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2-fluoro-4-methoxyphenyl)-1-ethanone (74457-86-6) → N-(4-Methoxyphenyl)-N-(1,1,1-trifluor-2-propyl)-2-fluor-4-methoxybenzamid (127817-88-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 66 percent / Br₂, NaOH / H₂O / 2 h / Ambient temperature

2: 89 percent / SOCl₂ / Heating

3: 64 percent / K₂CO₃ / 2 h / 80 °C

With sodium hydroxide; thionyl chloride; bromine; potassium carbonate; In water;

DOI:10.1002/ardp.19903230204

Reference yield:

2-fluoro-4-methoxy-benzoic acid (394-42-3) → N-(4-Methoxyphenyl)-N-(1,1,1-trifluor-2-propyl)-2-fluor-4-methoxybenzamid (127817-88-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / SOCl₂ / Heating

2: 64 percent / K₂CO₃ / 2 h / 80 °C

With thionyl chloride; potassium carbonate;

DOI:10.1002/ardp.19903230204

Reference yield: 69.0%

N-(4-Methoxyphenyl)-N-(1,1,1-trifluor-2-propyl)-2-fluor-4-methoxybenzamid (127817-88-3) → N-(4-Hydroxyphenyl)-N-(1,1,1-trifluor-2-propyl)-2-fluor-4-hydroxybenzamid (127851-72-3)

Guidance literature:

With boron tribromide; In dichloromethane; 1) 30 min, -60 deg C 2) 4h, room temperature;

DOI:10.1002/ardp.19903230204

upstream raw materials:

2-fluoro-4-methoxy-benzoic acid

1-(2-fluoro-4-methoxyphenyl)-1-ethanone

Downstream raw materials:

N-(4-Hydroxyphenyl)-N-(1,1,1-trifluor-2-propyl)-2-fluor-4-hydroxybenzamid

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