Dimethyl 4,5-dihydro-5-(phenylthio)-2-<2(E)-phenylvinyl>oxazole-4,4-dicarboxylate

Base Information

Chemical Name:Dimethyl 4,5-dihydro-5-(phenylthio)-2-<2(E)-phenylvinyl>oxazole-4,4-dicarboxylate
CAS No.:153180-32-6
Molecular Formula:C₂₁H₁₉NO₅S
Molecular Weight:397.452
Hs Code.:

Synonyms:Dimethyl 4,5-dihydro-5-(phenylthio)-2-<2(E)-phenylvinyl>oxazole-4,4-dicarboxylate

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Chemical Property of Dimethyl 4,5-dihydro-5-(phenylthio)-2-<2(E)-phenylvinyl>oxazole-4,4-dicarboxylate

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Technology Process of Dimethyl 4,5-dihydro-5-(phenylthio)-2-<2(E)-phenylvinyl>oxazole-4,4-dicarboxylate

There total 7 articles about Dimethyl 4,5-dihydro-5-(phenylthio)-2-<2(E)-phenylvinyl>oxazole-4,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7205-91-6
phenylthiomethyl chloride

: 153180-32-6
Dimethyl 4,5-dihydro-5-(phenylthio)-2-<2(E)-phenylvinyl>oxazole-4,4-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: NaOMe / TBAB / dimethylformamide / 16 h / Ambient temperature

2: 98 percent / TFA / CH₂Cl₂ / Ambient temperature

3: 88 percent / pyridine / CH₂Cl₂ / 1 h / Ambient temperature

4: 1.) NCS, 2.) EtN(i-Pr)2 / 1.) DMF, 0 deg C to r.t., 16 h, 2.) r.t., 10 h

With pyridine; N-chloro-succinimide; sodium methylate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; tetrabutylammomium bromide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00073a040

Reference yield:

: 61172-70-1
dimethyl 2-(tert-butoxycarbonylamino)malonate

: 153180-32-6
Dimethyl 4,5-dihydro-5-(phenylthio)-2-<2(E)-phenylvinyl>oxazole-4,4-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: NaOMe / TBAB / dimethylformamide / 16 h / Ambient temperature

2: 98 percent / TFA / CH₂Cl₂ / Ambient temperature

3: 88 percent / pyridine / CH₂Cl₂ / 1 h / Ambient temperature

4: 1.) NCS, 2.) EtN(i-Pr)2 / 1.) DMF, 0 deg C to r.t., 16 h, 2.) r.t., 10 h

With pyridine; N-chloro-succinimide; sodium methylate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; tetrabutylammomium bromide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00073a040

Reference yield:

: 102-92-1,17082-09-6
Cinnamoyl chloride

: 153180-32-6
Dimethyl 4,5-dihydro-5-(phenylthio)-2-<2(E)-phenylvinyl>oxazole-4,4-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / pyridine / CH₂Cl₂ / 1 h / Ambient temperature

2: 1.) NCS, 2.) EtN(i-Pr)2 / 1.) DMF, 0 deg C to r.t., 16 h, 2.) r.t., 10 h

With pyridine; N-chloro-succinimide; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/jo00073a040