2-hydroxy-4,5-dimethoxyphenyl glyoxylic acid

Base Information

• Chemical Name: 2-hydroxy-4,5-dimethoxyphenyl glyoxylic acid
• CAS No.: 52196-79-9
• Molecular Formula: C₁₀H₁₀O₆
• Molecular Weight: 226.186
• Mol file: 52196-79-9.mol

Synonyms:2-hydroxy-4,5-dimethoxyphenyl glyoxylic acid

Chemical Property of 2-hydroxy-4,5-dimethoxyphenyl glyoxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-hydroxy-4,5-dimethoxyphenyl glyoxylic acid

There total 6 articles about 2-hydroxy-4,5-dimethoxyphenyl glyoxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

2,4,5-trimethoxyphenylglyoxylic acid (38445-02-2) → 2-hydroxy-4,5-dimethoxyphenyl glyoxylic acid (52196-79-9)

Guidance literature:

With aluminum (III) chloride; In dichloromethane; at 50 ℃; for 3h; Microwave irradiation;

DOI:10.3390/molecules25081978

Reference yield:

1,2,4-trimethoxy-benzene (135-77-3) → 2-hydroxy-4,5-dimethoxyphenyl glyoxylic acid (52196-79-9)

Guidance literature:

Multi-step reaction with 3 steps

1: titanium tetrachloride / dichloromethane / 2 h / -20 °C

2: potassium hydroxide / methanol / 2 h

3: aluminum (III) chloride / dichloromethane / 3 h / 50 °C / Microwave irradiation

With aluminum (III) chloride; titanium tetrachloride; potassium hydroxide; In methanol; dichloromethane;

DOI:10.3390/molecules25081978

Reference yield:

2',4',5'-trimethoxyacetophenone (1818-28-6) → 2-hydroxy-4,5-dimethoxyphenyl glyoxylic acid (52196-79-9)

Guidance literature:

Multi-step reaction with 2 steps

1: selenium(IV) oxide; pyridine / 4 h / 80 °C

2: aluminum (III) chloride / dichloromethane / 3 h / 50 °C / Microwave irradiation

With pyridine; selenium(IV) oxide; aluminum (III) chloride; In dichloromethane;

DOI:10.3390/molecules25081978

upstream raw materials:

(2-hydroxy-4,5-dimethoxy-phenyl)-glyoxylic acid ethyl ester

2',4',5'-trimethoxyacetophenone

1,2,4-trimethoxy-benzene

2,4,5-trimethoxyphenylglyoxylic acid

Downstream raw materials:

(2,4,5-trimethoxy-phenyl)-glyoxylic acid methyl ester