1818-28-6

Basic information

• Product Name: 2',4',5'-TRIMETHOXYACETOPHENONE
• Synonyms: 2',4',5'-TRIMETHOXYACETOPHENONE;2,4,5-TRIMETHOXYACETOPHENONE;1-(2,4,5-Trimethoxyphenyl)ethanone;Acetophenone, 2',4',5'-trimethoxy-;Ethanone, 1-(2,4,5-trimethoxyphenyl)-;1-(2,4,5-trimethoxyphenyl)ethan-1-one
• CAS NO: 1818-28-6
• Molecular Formula: C₁₁H₁₄O₄
• Molecular Weight: 210.23
• EINECS: 217-333-4
• Product Categories: Aromatic Acetophenones & Derivatives (substituted)
• Mol File: 1818-28-6.mol
• Article Data: 13

Chemical Properties

• Melting Point: 98-102°C
• Boiling Point: 328.3 ºC at 760 mmHg
• Flash Point: 144.4 ºC
• Appearance: /
• Density: 1.089 g/cm³
• CAS DataBase Reference: 2',4',5'-TRIMETHOXYACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2',4',5'-TRIMETHOXYACETOPHENONE(1818-28-6)
• EPA Substance Registry System: 2',4',5'-TRIMETHOXYACETOPHENONE(1818-28-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 1818-28-6(Hazardous Substances Data)

Usage

Preparation

Preparation by reaction of acetyl chloride with hydroxyhydroquinone trimethyl ether in the presence of aluminium chloride.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 33, p. 1155, 1990 DOI: 10.1021/jm00166a012

Upstream product

• 490-64-2 asaronic acid 
• 75-05-8 acetonitrile 
• 41317-93-5 2,4,5-trimethoxy-α-methylbenzenemethanol 
• 4460-86-0 asaraldehyde 
• 494-40-6 asarone 
• 135-77-3 1,2,4-trimethoxy-benzene 
• 75-36-5 acetyl chloride 
• 7446-70-0 aluminium trichloride 
• 77-78-1 dimethyl sulfate 
• 108-24-7 acetic anhydride 
• 70460-31-0 2',4',5,5',6,7,8-heptamethoxyflavone 
• 875213-77-7 1-(2,4,5-triacetoxy-phenyl)-ethanone 
• 20628-06-2 2-hydroxy-4,5-dimethoxyacetophenone 

Downstream Products

• 14227-14-6 1,2,4-trimethoxy-5-nitrobenzene 
• 1350753-33-1 (2E)-3-{4-[(E)-2-(4-hydroxy-3,5-dimethoxyphenyl)ethenyl]phenyl}-1-(2,4,5-trimethoxyphenyl)prop-2-en-1-one 
• 1364211-84-6 1-(2,4,5-trimethoxyphenyl)-3-(4-iodophenyl)prop-2-en-1-one 
• 52196-79-9 2-hydroxy-4,5-dimethoxyphenyl glyoxylic acid 
• 38445-02-2 2,4,5-trimethoxyphenylglyoxylic acid 
• 172751-43-8 2,2',4',5'-tetramethoxychalcone 
• 14469-95-5 2,2',4,4',5,5'-hexamethoxychalcone 
• 7298-39-7 4',5'-bis(benzyloxy)-2'-hydroxyacetophenone 

Relevant articles and documents

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Compound for treating or preventing hepatopathy (by machine translation)

The invention discloses a compound, an optical isomer or a pharmaceutically acceptable salt, an optical isomer or a pharmaceutically acceptable salt thereof for treating or preventing hepatopathy, and the compound, optical isomer or pharmaceutically acceptable salt thereof can be applied to the preparation of a medicine for treating or preventing liver diseases. (by machine translation)

Hexafluoro-2-propanol-Promoted Intermolecular Friedel-Crafts Acylation Reaction

The intermolecular Friedel-Crafts acylation was carried out in hexafluoro-2-propanol to yield aryl and heteroaryl ketones at room temperature without any additional reagents.