4-hydroxy-6-methyl-3-(1-(2-(4-tolylthiazol-2-yl)hydrazono)ethyl)-2H-pyran-2-one

Base Information

• Chemical Name: 4-hydroxy-6-methyl-3-(1-(2-(4-tolylthiazol-2-yl)hydrazono)ethyl)-2H-pyran-2-one
• CAS No.: 338978-03-3
• Molecular Formula: C₁₈H₁₇N₃O₃S
• Molecular Weight: 355.417

Synonyms:4-hydroxy-6-methyl-3-(1-(2-(4-tolylthiazol-2-yl)hydrazono)ethyl)-2H-pyran-2-one

Chemical Property of 4-hydroxy-6-methyl-3-(1-(2-(4-tolylthiazol-2-yl)hydrazono)ethyl)-2H-pyran-2-one

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Technology Process of 4-hydroxy-6-methyl-3-(1-(2-(4-tolylthiazol-2-yl)hydrazono)ethyl)-2H-pyran-2-one

There total 2 articles about 4-hydroxy-6-methyl-3-(1-(2-(4-tolylthiazol-2-yl)hydrazono)ethyl)-2H-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

4-(bromoacetyl)toluene (619-41-0) + 3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one thiosemicarbazone (75843-20-8) → 4-hydroxy-6-methyl-3-(1-(2-(4-tolylthiazol-2-yl)hydrazono)ethyl)-2H-pyran-2-one (338978-03-3)

Guidance literature:

With sodium acetate; In ethanol; for 0.416667h; Reflux;

DOI:10.1007/s00044-011-9859-y

Reference yield:

3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one (771-03-9) → 4-hydroxy-6-methyl-3-(1-(2-(4-tolylthiazol-2-yl)hydrazono)ethyl)-2H-pyran-2-one (338978-03-3)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / Reflux

2: sodium acetate / ethanol / 0.42 h / Reflux

With sodium acetate; In ethanol;

DOI:10.1007/s00044-011-9859-y

Reference yield: 59.0%

4-hydroxy-6-methyl-3-(1-(2-(4-tolylthiazol-2-yl)hydrazono)ethyl)-2H-pyran-2-one (338978-03-3) → 1-(5-hydroxy-3-methyl-1-(4-tolylthiazol-2-yl)-1H-pyrazol-4-yl)butane-1,3-dione (1351946-52-5)

Guidance literature:

With acetic acid; In ethanol; for 2h; Reflux;

DOI:10.1007/s00044-011-9859-y

upstream raw materials:

4-(bromoacetyl)toluene

3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one thiosemicarbazone

3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one

Downstream raw materials:

3-methyl-4-(3-methylisoxazol-5-yl)-1-(4-p-tolylthiazol-2-yl)-1H-pyrazol-5-ol

1-(5-hydroxy-3-methyl-1-(4-tolylthiazol-2-yl)-1H-pyrazol-4-yl)butane-1,3-dione

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